2009 Fiscal Year Final Research Report
Development of negative signal-inducing anti-allergic IgE
| Project/Area Number |
19790084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
NAKAMURA Ryosuke National Institute of Health Sciences, 代謝生化学部, 主任研究官 (50333357)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 免疫化学 / 抗アレルギー薬 / IgE / マスト細胞 / シグナル伝達 / アレルギー試験 |
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| Research Abstract |
Mast cells play important roles in the allergic reactions, and they express active signal-inducing high-affinity IgE receptors (FcεRI) and negative signal-inducing low-affinity IgG receptors (FcγRIIB) on their surface. In this study, new IgE molecule which may bind FcεRI and FcγRIIB simultaneously was genetically developed.
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[Journal Article] Effects of developmental hypothyroidism induced by maternal administration of methimazole or propylthiouracil on the immune system of rats2007
Author(s)
Nakamura, R., Teshima, R., Hachisuka, A., Sato, Y., Takagi, K., Nakamura, R., Woo, G.H., Shibutani, M., Sawada, J.
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Journal Title
International Immunopharmacology Vol.7、No.13
Pages: 1630-1638
Peer Reviewed
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