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2008 Fiscal Year Final Research Report

Regulation of the function of blood?brain barrier by adipocytokine in obesity

Research Project

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Project/Area Number 19790199
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionFukuoka University

Principal Investigator

YAMAUCHI Atsushi  Fukuoka University, 薬学部, 准教授 (90341453)

Project Period (FY) 2007 – 2008
Keywords肥満 / 血液脳関門 / アディポサイトカイン / 炎症性サイトカイン
Research Abstract

近年肥満病態で注目されている血中アディポサイトカインの血液脳関門(BBB)機能に及ぼす影響は不明である。本研究では、アディポサイトカインによるBBB機能制御機構を追求することを目的とし、BBB構成細胞のペリサイトに着目して検討した。アディポネクチンのBBB機能に対する作用はなかったが、攻撃因子として一酸化窒素、オンコスタチンM、防御因子としてTGF-βを抽出することができた。またBBBの病変化の過程にはペリサイトの機能低下が関与していることが判った。

  • Research Products

    (6 results)

All 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results)

  • [Journal Article] Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway2009

    • Author(s)
      Takata F, Dohgu S, Nishioku T, Takahashi H, Harada E, Makino I, Nakashima M, Yamauchi A, Kataoka Y.
    • Journal Title

      Neurosci Lett 449(1)

      Pages: 71-5

    • Peer Reviewed
  • [Journal Article] Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells.2008

    • Author(s)
      Takata F, Sumi N, Nishioku T, Harada E, Wakigawa T, Shuto H, Yamauchi A, Kataoka Y.
    • Journal Title

      Neurosci Lett. 441(2)

      Pages: 163-164

    • Peer Reviewed
  • [Journal Article] Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia- reoxygenation damage in vitro.2007

    • Author(s)
      Dohgu S, Nishioku T, Sumi N, Takata F, Nakagawa S, Naito M, Tsuruo T, Yamauchi A, Shuto H, Kataoka Y.
    • Journal Title

      Cell Mol Neurobiol. 27(7)

      Pages: 889-899

    • Peer Reviewed
  • [Journal Article] An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function.2007

    • Author(s)
      Yamauchi A, Dohgu S, Nishioku T, Shuto H, Naito M, Tsuruo T, Sawada Y, Kataoka Y.
    • Journal Title

      Cell Mol Neurobiol. 27(3)

      Pages: 263-270

    • Peer Reviewed
  • [Journal Article] Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier.2007

    • Author(s)
      Takata F, Dohgu S, Yamauchi A, Sumi N, Nakagawa S, Naito M, Tsuruo T, Shuto H, Kataoka Y.
    • Journal Title

      Cell Mol Neurobiol. 27(3)

      Pages: 317-328

    • Peer Reviewed
  • [Journal Article] Detachment of Brain Pericytes from the Basal Lamina is involved in Disruption of the Blood-Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice.

    • Author(s)
      Nishioku T, Dohgu S, Takata F, Eto T, Ishikawa N, Kodama KB, Nakagawa S, Yamauchi A, Kataoka Y.
    • Journal Title

      Cell Mol Neurobiol (in press)

    • Peer Reviewed

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Published: 2010-06-10   Modified: 2016-04-21  

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