A basic research for phosphatidylinositol 3-kinase inhibitor utilization in lymphoma

2009 Fiscal Year Final Research Report

• Project/Area Number: 19790273
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Japanese Foundation For Cancer Research
• Principal Investigator: TAKEUCHI Kengo Japanese Foundation For Cancer Research, 癌研究所病理部, 研究員 (40323612)
• Project Period (FY): 2007 – 2009
• Keywords: リンパ腫 / PI3K

Research Abstract

of the cases are accompanied by clinical information. In order to develop a biomarker analysis for PI3K pathway activation, we tried to immunostain the TMA slides for a phosphorylated substance X using various enhancement techniques. However, we failed to obtain a positive result. We also analyzed the methylation status of PTEN, which suppresses the PI3K pathway. Methylation-specific PCR revealed that the gene was methylated in 4 of 15 cases.

Research Products

• [Journal Article] Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations (2010)
  • Author(s): Hiramatsu M, Ninomiya H, Inamura K, Nomura K, Takeuchi K, Satoh Y, Okumura S, Nakagawa K, Yamori T, Matsuura M, Morikawa T, Ishikawa Y.
  • Journal Title: Lung Cancer
• [Journal Article] Statin-independent prognosis of patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy (2010)
  • Author(s): Ennishi D, Asai H, Maeda Y, Shinagawa K, Ikeda K, Yokoyama M, Terui Y, Takeuchi K, Yoshino T, Matsuo K, Hatake K, Tanimoto M.
  • Journal Title: Ann Oncol. 21 Pages: 1217-1221
• [Journal Article] Is Statin Use Really Associated With Efficacy of Rituximab? (2010)
  • Author(s): Asai H, Yokoyama M, Terui Y, Ennishi D, Takeuchi K, Hatake K.
  • Journal Title: J Clin Oncol.
• [Journal Article] Identification of CD20 C-Terminal Deletion Mutations Associated with Loss of CD20 Expression in Non-Hodgkin's Lymphoma (2009)
  • Author(s): Terui Y, Mishima Y, Sugimura N, Kojima K, Sakurai T, Kuniyoshi R, Taniyama A, Yokoyama M, Sakajiri S, Takeuchi K, Watanabe C, Takahashi S, Ito Y, Hatake K.
  • Journal Title: Clin Cancer Res. 15 Pages: 2523-2530
• [Journal Article] KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer (2009)
  • Author(s): Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, Takada S, Ueno T, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
  • Journal Title: Clin Cancer Res. 15 Pages: 3143-3149
• [Journal Article] Frequent inactivation of A20 in B-cell lymphomas (2009)
  • Author(s): Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S.
  • Journal Title: Nature 459 Pages: 712-716
• [Journal Article] Soluble interleukin-2 receptor retains prognostic value in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP (RCHOP) therapy (2009)
  • Author(s): Ennishi D, Yokoyama M, Terui Y, Asai H, Sakajiri S, Mishima Y, Takahashi S, Komatsu H, Ikeda K, Takeuchi K, Tanimoto M, Hatake K.
  • Journal Title: Ann Oncol. 20 Pages: 526-533
• [Journal Article] CD5 expression is potentially predictive of poor outcome among biomarkers in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy. (2008)
  • Author(s): Ennishi D, Takeuchi K, Yokoyama M, Asai H, Mishima Y, Terui Y, Takahashi S, Komatsu H, Ikeda K, Yamaguchi M, Suzuki R, Tanimoto M, Hatake K.
  • Journal Title: Ann Oncol 19 Pages: 1921-1926
• [Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients (2007)
  • Author(s): Oyama T, Yamamoto K, Asano N, Oshiro A, Suzuki R, Kagami Y, Morishima Y, Takeuchi K, Izumo T, Mori S, Ohshima K, Suzumiya J, Nakamura N, Abe M, Ichimura K, Sato Y, Yoshino T, Naoe T, Shimoyama Y, Kamiya Y, Kinoshita T, Nakamura S.
  • Journal Title: Clin Cancer Res. 13 Pages: 5124-5132
• [Journal Article] Rituximab plus CHOP as an initial chemotherapy for patients with disseminated MALT lymphoma (2007)
  • Author(s): Ennishi D, Yokoyama M, Mishima Y, Watanabe C, Terui Y, Takahashi S, Takeuchi K, Ikeda K, Tanimoto M, Hatake K.
  • Journal Title: Leuk Lymphoma 48 Pages: 2241-2243
• [Presentation] Lymphomatoid gastropathy:本邦発の新しいNK細胞増殖症 (2009)
  • Author(s): 竹内賢吾
  • Organizer: 第55回日本病理学会秋季特別総会
  • Place of Presentation: 九段会館
  • Year and Date: 2009-11-19
• [Presentation] T/NK細胞リンパ腫 (2009)
  • Author(s): 竹内賢吾
  • Organizer: 第49回日本リンパ網内系学会
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2009-07-10