2009 Fiscal Year Final Research Report
A basic research for phosphatidylinositol 3-kinase inhibitor utilization in lymphoma
| Project/Area Number |
19790273
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
TAKEUCHI Kengo Japanese Foundation For Cancer Research, 癌研究所病理部, 研究員 (40323612)
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| Project Period (FY) |
2007 – 2009
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| Keywords | リンパ腫 / PI3K |
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| Research Abstract |
of the cases are accompanied by clinical information. In order to develop a biomarker analysis for PI3K pathway activation, we tried to immunostain the TMA slides for a phosphorylated substance X using various enhancement techniques. However, we failed to obtain a positive result. We also analyzed the methylation status of PTEN, which suppresses the PI3K pathway. Methylation-specific PCR revealed that the gene was methylated in 4 of 15 cases.
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Author(s)
Hiramatsu M, Ninomiya H, Inamura K, Nomura K, Takeuchi K, Satoh Y, Okumura S, Nakagawa K, Yamori T, Matsuura M, Morikawa T, Ishikawa Y.
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Journal Title
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[Journal Article] Statin-independent prognosis of patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy2010
Author(s)
Ennishi D, Asai H, Maeda Y, Shinagawa K, Ikeda K, Yokoyama M, Terui Y, Takeuchi K, Yoshino T, Matsuo K, Hatake K, Tanimoto M.
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Journal Title
Ann Oncol. 21
Pages: 1217-1221
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[Journal Article] Identification of CD20 C-Terminal Deletion Mutations Associated with Loss of CD20 Expression in Non-Hodgkin's Lymphoma2009
Author(s)
Terui Y, Mishima Y, Sugimura N, Kojima K, Sakurai T, Kuniyoshi R, Taniyama A, Yokoyama M, Sakajiri S, Takeuchi K, Watanabe C, Takahashi S, Ito Y, Hatake K.
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Journal Title
Clin Cancer Res. 15
Pages: 2523-2530
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[Journal Article] KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer2009
Author(s)
Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, Takada S, Ueno T, Yamashita Y, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y, Mano H.
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Journal Title
Clin Cancer Res. 15
Pages: 3143-3149
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[Journal Article] Frequent inactivation of A20 in B-cell lymphomas2009
Author(s)
Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S.
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Journal Title
Nature 459
Pages: 712-716
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[Journal Article] Soluble interleukin-2 receptor retains prognostic value in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP (RCHOP) therapy2009
Author(s)
Ennishi D, Yokoyama M, Terui Y, Asai H, Sakajiri S, Mishima Y, Takahashi S, Komatsu H, Ikeda K, Takeuchi K, Tanimoto M, Hatake K.
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Journal Title
Ann Oncol. 20
Pages: 526-533
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[Journal Article] CD5 expression is potentially predictive of poor outcome among biomarkers in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy.2008
Author(s)
Ennishi D, Takeuchi K, Yokoyama M, Asai H, Mishima Y, Terui Y, Takahashi S, Komatsu H, Ikeda K, Yamaguchi M, Suzuki R, Tanimoto M, Hatake K.
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Journal Title
Ann Oncol 19
Pages: 1921-1926
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[Journal Article] Age-related EBV-associated B-cell lymphoproliferative disorders constitute a distinct clinicopathologic group: a study of 96 patients2007
Author(s)
Oyama T, Yamamoto K, Asano N, Oshiro A, Suzuki R, Kagami Y, Morishima Y, Takeuchi K, Izumo T, Mori S, Ohshima K, Suzumiya J, Nakamura N, Abe M, Ichimura K, Sato Y, Yoshino T, Naoe T, Shimoyama Y, Kamiya Y, Kinoshita T, Nakamura S.
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Journal Title
Clin Cancer Res. 13
Pages: 5124-5132
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