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2009 Fiscal Year Final Research Report

Expression analysis of N-Myc downstream regulated gene 2 (Ndrg2) using the embryonic spinal cord and the adult brain

Research Project

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Project/Area Number 19790849
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

TAKAHASHI Kou  National Center of Neurology and Psychiatry, 老人精神保健部, 外来研究員 (20415582)

Project Period (FY) 2007 – 2009
Keywords精神薬理 / 抗うつ薬 / アストロサイト / 神経幹細胞
Research Abstract

We have reported that the expression of Ndrg2 was decreased after chronic antidepressant treatment and electroconvulsive treatment in rat frontal cortex. However, roles of Ndrg2 in the central nervous system were poorly understood. In the present study, we demonstrated that the expression of Ndrg2 was detected in neuronal stem cells and astrocyte in both the embryonic spinal cord and the adult brain. These results may indicate that Ndrg2 involved in the mechanisms of proliferation and differentiation in neuronal stem cells.

  • Research Products

    (12 results)

All 2010 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.2010

    • Author(s)
      Yamada, M., Takahashi, K., Ukai, W., Hashimoto, E., Saito, T., Yamada M.
    • Journal Title

      Neuroreport 21(2)

      Pages: 138-142

    • Peer Reviewed
  • [Journal Article] Induction of the transcription factor Math2 and its target gene Prg1 after chronic treatment with selective serotonin reuptake inhibitors in rat brain.2009

    • Author(s)
      Yamada, M., Shida, Y., Takahashi, K., Yamada M.
    • Journal Title

      J. Mental Health 55

      Pages: 103-109

    • Peer Reviewed
  • [Journal Article] Gene expression profiling reveals complex changes in the olfactory bulbectomy model of depression after chronic treatment with antidepressants.2008

    • Author(s)
      Takahashi, K., Saitoh, A., Yamada, M., Maruyama, Y., Hirose, N., Kamei, J., Yamada, M.
    • Journal Title

      J Pharmacol. Sci. 108(3)

      Pages: 320-334

    • Peer Reviewed
  • [Journal Article] Prg1 is regulated by the basic helix-loop-helix transcription factor Math2.2008

    • Author(s)
      Yamada, M., Shida Y., Takahashi, K., Tanioka T., Nakano Y., Tobe T., Yamada, M.
    • Journal Title

      J Neurochem 106(6)

      Pages: 2375-2384

    • Peer Reviewed
  • [Journal Article] Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway.2008

    • Author(s)
      Maruyama, Y., Yamada, M., Takahashi, K., Yamada, M.
    • Journal Title

      Biochem. Biophys. Res. Comm. 374

      Pages: 737-741

    • Peer Reviewed
  • [Journal Article] Antidepressant-like effects of the delta-opioid receptor agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S, 5R)-2, 5-di methyl-4-(2-propenyl)-1-pi perazinyl]-(3-methoxyphenyl)methyl]-N, N -diethylbenzamide] in an olfactory bulbectomized rat model.2008

    • Author(s)
      Saitoh, A., Yamada, M., Yamada, M., Takahashi K., Yamaguchi, K., Murasawa, H., Nakatani, A., Tatsumi, Y., Hirose, N., Kamei, J.
    • Journal Title

      Brain research 1208

      Pages: 160-169

    • Peer Reviewed
  • [Presentation] A glutamate release inhibitor rapidly attenuates hyperemotional responses in OBX rats.2009

    • Author(s)
      Inagaki, M., Takahashi, K., Saitoh, A., Yamada, M., Iwai, T., Nakaani, A., Murasawa, H., Yoshida, M., Yamaguchi, K., Yamada, M.
    • Organizer
      The 1st Meeting of the Asian College of Neuropsychopharmacology
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      20091100
  • [Presentation] An antidepressant related transcription factor Math2 regulates Prg1 expression and involves in neurite differentiation.2009

    • Author(s)
      Yamada, M., Yamada, M., Shida Y., Takahashi, K., Tanioka T., Nakano Y., Tobe T.
    • Organizer
      The 1st Meeting of the Asian College of Neuropsychopharmacology
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      20091100
  • [Presentation] Chronic treatment with a selective opioid-delta agonist SNC80 affects the expression of excitatory amino-acid transporter genes in frontal cortex of olfactory bulbectomized rat.2009

    • Author(s)
      Saitoh, A., Yamada, M., Takahashi, K., Iwai, T., Inagaki, M., Yamada, M.
    • Organizer
      The 1st Meeting of the Asian College of Neuropsychopharmacology
    • Place of Presentation
      Kyoto International Conference Center
    • Year and Date
      20091100
  • [Presentation] The RING finger domain of Kf-1 is required for ubiquitin ligase activity and subcellular redistribution.2007

    • Author(s)
      丸山良亮, 山田美佐, 高橋弘, 山田光彦
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      20071200
  • [Presentation] 抗うつ薬の作用メカニズムに関わる転写因子ADRG701が制御する下流遺伝子の探索2007

    • Author(s)
      志田美子, 高橋弘, 山田美佐, 中野泰子, 戸部敞山田光彦
    • Organizer
      BMB2007
    • Place of Presentation
      横浜
    • Year and Date
      20071200
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nimh/rojin/

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Published: 2011-06-18   Modified: 2016-04-21  

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