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2009 Fiscal Year Final Research Report

Gene expressions associated to chemosensitivity in pancreatic cancer patients

Research Project

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Project/Area Number 19790959
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

KURAMOCHI Hidekazu  Tokyo Women's Medical University, 医学部, 助教 (30287362)

Project Period (FY) 2007 – 2009
Keywords膵臓癌 / 化学療法 / S-1 / Gemcitabine / DNAマイクロアレイ
Research Abstract

We evaluated the gene expression levels associated with chemosentitivity in 81 pancreatic cancer patients after complete resection using real-time PCR. DPD, DHFR, FPGS, and GGH were found to be biomarkers of survival in those patients. We verified the function of those genes in vitro experiments.

  • Research Products

    (23 results)

All 2010 2009 2008 2007 Other 0

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (10 results)

  • [Journal Article] Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases.2010

    • Author(s)
      Kuramochi H, Hayashi K, Nakajima G, et al, 他4名、1番目
    • Journal Title

      Cancer Chemother Pharmacol. 65(5)

      Pages: 825-31

    • Peer Reviewed
  • [Journal Article] Loss of heterozygosity at thymidylate synthase locus in Barrett's metaplasia, dysplasia, and carcinoma sequences.2009

    • Author(s)
      Kuramochi H, Uchida K, Peters JH, et al, 他5名、1番目
    • Journal Title

      BMC Cancer. 9

      Pages: 157

    • Peer Reviewed
  • [Journal Article] Validation of a rodent model of Barrett's esophagus using quantitative gene expression profiling.2009

    • Author(s)
      Oh DS, DeMeester SR, Dunst CM,, Kuramochi H, et al, 他8名、6番目
    • Journal Title

      Surg Endosc 23(6)

      Pages: 1346-52

    • Peer Reviewed
  • [Journal Article] The analysis of CCR4+/CXCR3+ cell ratio in gastrointestinal cancer patients receiving chemotherapy or immunotherapy2008

    • Author(s)
      Sakuyama R, Aruga A, Kuramochi H, 他4名、3番
    • Journal Title

      Gan To Kagaku Ryoho 35(12)

      Pages: 2259-61

    • Peer Reviewed
  • [Journal Article] Three cases of stomatitis caused by chemotherapy for gastrointestinal cancer that responded well to lafutidine2008

    • Author(s)
      Uchida K, Hayashi K, Kuramochi H, et al, 他2名、3番目
    • Journal Title

      Gan To Kagaku Ryoho 35(8)

      Pages: 1435-8

    • Peer Reviewed
  • [Journal Article] ERCC1 codon 118 polymorphism is a useful prognostic marker in patients with pancreatic cancer treated with platinum-based chemotherapy.2008

    • Author(s)
      Kamikozuru H, Kuramochi H, Hayashi K, 他2名、2番目
    • Journal Title

      Int J Oncol. 32(5)

      Pages: 1091-6

    • Peer Reviewed
  • [Journal Article] High intratumoral dihydropyrimidine dehydrogenase. A levels in pancreatic cancer associated with a high rate of response to S-1.2008

    • Author(s)
      Kuramochi H, Hayashi K, Uchida K, et al, 他6名、1番目
    • Journal Title

      Cancer Chemother Pharmacol. 63(1)

      Pages: 85-9

    • Peer Reviewed
  • [Journal Article] Messenger RNA expression of vascular endothelial growth factor and its receptors in primary colorectal cancer and corresponding liver metastasis.2008

    • Author(s)
      Kobayashi H, Sugihara K, Kuramochi H, 他7名、6番目
    • Journal Title

      Ann Surg Oncol 15(4)

      Pages: 1232-8

    • Peer Reviewed
  • [Journal Article] Thymidylate synthase polymorphisms and mRNA expression are independent chemotherapy predictive markers in esophageal adenocarcinoma patients.2008

    • Author(s)
      Kuramochi H, Tanaka K, Oh D, et al, 他8名、1番目
    • Journal Title

      Int J Oncol. 32(1)

      Pages: 201-8

    • Peer Reviewed
  • [Journal Article] Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia.2007

    • Author(s)
      Vallbohmer D, Marjoram P, Kuramochi H, et al, 他9名、3番目
    • Journal Title

      J Gastrointest Surg. 11(9)

      Pages: 1095-104

    • Peer Reviewed
  • [Journal Article] DPD is a molecular determinant of capecitabine efficacy in colorectal cancer.2007

    • Author(s)
      Vallbohmer D, Yang DY, Kuramochi H, 他6名、3番目
    • Journal Title

      Int J Oncol 31(2)

      Pages: 413-8

    • Peer Reviewed
  • [Journal Article] Reduction of interleukin 8 gene expression in reflux esophagitis and Barrett's esophagus with antireflux surgery.2007

    • Author(s)
      Oh DS, DeMeester SR, Kuramochi H, 他8名、5番目
    • Journal Title

      Arch Surg 142(6)

      Pages: 554-9

    • Peer Reviewed
  • [Journal Article] Combination therapy of S-1 and CDDP for patients with colorectal cancer.2007

    • Author(s)
      Uchida K, Hayashi K, Kuramochi H, 他3名、3番目
    • Journal Title

      J Cancer Res Clin Oncol 133(11)

      Pages: 841-6

    • Peer Reviewed
  • [Presentation] S-1+l-OHP療法を施行した大腸癌症例におけるERCC1多型の感受性マーカーとしての有用性。2009

    • Author(s)
      倉持英和, ほか
    • Organizer
      第47回日本癌治療学会総会口演
    • Place of Presentation
      横浜
    • Year and Date
      20091022-20091024
  • [Presentation] Correlation of folate-metabolizing enzymes with the outcomes of patients treated with gemcitabine or S-1 for adjuvant chemotherapy of advanced pancreatic cancer.2009

    • Author(s)
      A. Nakamura, H. Kuramochi
    • Organizer
      AACR meeting 2009
    • Place of Presentation
      Denver, USA
    • Year and Date
      20090418-20090422
  • [Presentation] 進行再発大腸癌に対するS-1+オキサリプラチン併用療法(SOX療法)の第一相試験。2008

    • Author(s)
      倉持英和, ほか
    • Organizer
      第46回日本癌治療学会総会口演
    • Place of Presentation
      名古屋
    • Year and Date
      20081030-20081101
  • [Presentation] 大腸癌原発巣と肝転移巣におけるEGFRmRNA発現レベルと蛋白発現との関連性の検討。2008

    • Author(s)
      倉持英和, ほか
    • Organizer
      第63回日本消化器外科学会総会口演
    • Place of Presentation
      札幌
    • Year and Date
      20080716-20080718
  • [Presentation] Thymidylate Synthase (TS)遺伝子多型と遺伝子発現の食道腺癌患者における化学療法感受性マーカーとしての有用性の検討。2008

    • Author(s)
      倉持英和, ほか
    • Organizer
      第6回日本臨床腫瘍学会口演
    • Place of Presentation
      福岡
    • Year and Date
      20080320-20080321
  • [Presentation] 大腸癌原発巣と肝転移巣におけるEpidermal Growth Factor Receptor (EGFR)の遺伝子発現量の検討。2007

    • Author(s)
      倉持英和, ほか
    • Organizer
      第62回日本消化器外科学会総会口演
    • Place of Presentation
      東京
    • Year and Date
      20070718-20070720
  • [Presentation] Epidermal growth factor receptor (EGFR) mRNA expression levels are strongly correlated between primary colorectal cancer and corresponding liver metastases.

    • Author(s)
      H. Kuramochi, K. Hayashi, K. Uchida, M. Yamamoto, K.D. Danenberg, P.V. Danenberg
    • Organizer
      2007 ASCO Annual Meeting No. 4106
    • Place of Presentation
      Chicago, USA
    • Year and Date
      00000601-00000605
  • [Presentation] The relationship between epidermal growth factor receptor (EGFR) mRNA levels and protein expression in primary colorectal cancer and corresponding liver metastases.

    • Author(s)
      H. Kuramochi, K. Hayashi, G. Nakajima, K.D. Danenberg, P.V. Danenberg, M. Yamamoto
    • Organizer
      2008 ASCO Annual Meeting Abstract No. 15021
    • Place of Presentation
      Chicago, USA
    • Year and Date
      00000530-00000603
  • [Presentation] Evaluation of thymidylate synthase and ERCC1 mRNA levels as predictive markers in colorectal cancer patients treated with S-1 and oxaliplatin.

    • Author(s)
      H. Kuramochi, K. Hayashi, G. Nakajima, H. Kamikozuru, M. Yamamoto.
    • Organizer
      2009 ASCO Annual Meeting Abstract No. 15071
    • Place of Presentation
      Orlando, USA
    • Year and Date
      00000529-00000602
  • [Presentation] High intratumoral Dihydropyrimidine0

    • Author(s)
      H. Kuramochi, K. Hayashi, H. Kamikozuru, G. Nakajima, T. Hatori, M. Yamamoto
    • Organizer
      IPRF Forum 2009
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      00000328

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Published: 2011-06-18   Modified: 2016-04-21  

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