2010 Fiscal Year Final Research Report
Role of heparan sulfate proteoglycan in joint development
| Project/Area Number |
19791036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
MATSUMOTO Yoshihiro Kyushu University, 医学研究院・整形外科, 助教 (10346794)
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| Project Period (FY) |
2007 – 2010
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| Keywords | ヘパラン硫酸 / 関節形成 / Bone morphogenetic protein / ノックアウトマウス |
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| Research Abstract |
To elucidate the pathogenesis of joint diseases, the roles of heparan sulfate (HS) in the joint development was investigated. Loss of HS in the cell surface causd the diffuse distribution of bone morphogenetic protein and the abnormal formation of mesenchymal condensation that was critical for the joint development. These results clearly indicated the essential and cell biological roles of HS in the joint development.
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