2009 Fiscal Year Final Research Report
Aquaporin as a target of a new therapy for brain edema
| Project/Area Number |
19791080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Nagoya City University |
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Principal Investigator |
YAMAUCHI Hiroki Nagoya City University, 大学院・医学研究科, 研究員 (00448713)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脳浮腫 / アクアポリン / アストロサイト / 中枢神経 |
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| Research Abstract |
The membrane pore proteins, aquaporins (AQPs), facilitate the osmotically driven passage of water and, in some instances, small solutes. AQPs play important roles in maintaining brain homeostasis. In this study, we observed that the expression of AQP4 was increased in cultured rat astrocytes through p38 MAPK or NF-kB, In addition, a p38 MAPK inhibitor, but not ERK and JNK inhibitors, and NF-kB inhibitors suppressed their expression in cultured astrocytes. NF-kB inhibitors and p38 MAPK inhibitor may protect astrocytes form the hypoxia-induced injury.
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