2012 Fiscal Year Final Research Report
A novel approach to cell adhesion/cytoskeleton research for exploring the epithelia cell system
| Project/Area Number |
19GS0313
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| Research Category |
Grant-in-Aid for Creative Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Takeshi 大阪大学, 生命機能/医学, 助教 (10452442)
SASAKI Hiroyuki 東京慈恵会医科大学, 医学部, 准教授 (60170693)
TAKEUCHI Kosei 新潟大学, 医歯学系, 準教授 (90206946)
YAMAZAKI Yuji 大阪大学, 生命機能/医学, 助教 (80527664)
TAMURA Atsushi 大阪大学, 医学, 助教 (00362525)
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| Project Period (FY) |
2007 – 2012
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| Keywords | 肝臓毛細胆管画分 / 上皮細胞 / タイトジャンクション(TJ) / アピカル膜 / 炎症 |
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| Research Abstract |
To understand how the biological functions of epithelial cell sheets are created in multicellular organisms, we aim to systematically examine the constitution and function of epithelial cell sheets. In addition to the previously identified components of cell-cell adhesion molecules, we have identified novel adhesion-related molecules using a method we developed for isolating cell-cell adhesion complexes. To study cell-sheet function, we have focused on the following points. 1) The regulation of biological functions by tight junctions, which control the microenvironment. 2) Signal transduction originating from the cell-cell adhesion apparatus, including the tight and adherens junctions. 3) The cooperative functional integration of the apical apparatus and the cytoskeleton. 4) The functional integration of apical membranes and cell-cell adhesion.
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