2019 Fiscal Year Annual Research Report
Directed Evolution of a Palette of Optogenetic Indicators for Multiplexed Imaging of Cellular Metabolism
| Project/Area Number |
19H00920
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| Research Institution | The University of Tokyo |
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Principal Investigator |
キャンベル ロバート.アール 東京大学, 大学院理学系研究科(理学部), 教授 (40831318)
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| Project Period (FY) |
2019-04-01 – 2020-03-31
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| Keywords | Protein Engineering / Fluorescence / Microscopy / Cell Biology |
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| Outline of Annual Research Achievements |
The goal of this project was to perform "Directed Evolution of a Palette of Optogenetic Indicators for Multiplexed Imaging of Cellular Metabolism" by using the Grant-in-Aid for Scientific Research (A). In this fiscal year, this grant enabled us to set up the laboratory for the study mentioned above. For example, we purchased a wide-field fluorescence microscopy, which Campbell lab is using to accelerate the development of a range of optogenetic indicators.
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| Research Progress Status |
令和元年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和元年度が最終年度であるため、記入しない。
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[Journal Article] A genetically encoded near-infrared fluorescent calcium ion indicator2019
Author(s)
Y. Qian (equal contribution), K.D. Piatkevich (equal contribution), B. McLarney (equal contribution), A.S. Abdelfattah, S. Mehta, M.H. Murdock, S. Gottschalk, R.S. Molina, W. Zhang, Y. Chen, J. Wu, M. Drobizhev, T.E. Hughes, J. Zhang, E.R. Schreiter, S. Shoham, D. Razansky, E.S. Boyden, and R.E. Campbell*
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Journal Title
Nat. Methods
Volume: 16
Pages: 171-174
DOI
Peer Reviewed / Int'l Joint Research
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