2023 Fiscal Year Final Research Report
Studies on development of control measures of Cryptocaryon irritans infectios based on integrated pest management
| Project/Area Number |
19H00948
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 40:Forestry and forest products science, applied aquatic science, and related fields
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Yoshinaga Tomoyoshi 東京大学, 大学院農学生命科学研究科(農学部), 特任教授 (20345185)
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| Co-Investigator(Kenkyū-buntansha) |
渡邊 勇歩 東京大学, 大学院農学生命科学研究科(農学部), 助教 (40895893)
白樫 正 近畿大学, 水産研究所, 准教授 (70565936)
伊藤 直樹 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (30502736)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 海産白点虫 / Cryptocaryon irritans / ワクチン / 化学療法 / 生態 / 概日リズム |
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| Outline of Final Research Achievements |
Research on the white spot disease of marine fishes caused by the parasitic ciliate, Cryptocaryon irritans, was conducted from the following four perspectives (I. Investigation of techniques for predicting outbreaks based on the ecological characteristics of the ciliate, II. Exploration of chemotherapeutic agents and investigation of their efficacy and safety, III. Investigation of vaccines using parasite-associated proteolytic enzymes as antigens and IV. Development of new in vitro culture methods)
For I, the details of the circadian rhythm of the release of infected larvae from cysts were clarified. For II and III, oral administration of ionophore antibiotics and DNA vaccines using genes of proteolytic enzymes were found to be effective for treatment and prophylaxis to some extent. For IV, an attempt was made to develop a culture method using apoptotic cells, but no better results were obtained than with the conventional method.
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| Free Research Field |
魚病学
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| Academic Significance and Societal Importance of the Research Achievements |
海産白点虫症は海産魚の陸上養殖や与える光周期によって、感染幼虫の放出時間を変化させることによって、のコントロールによって被害を抑える手法の開発に資するものである。また、イオノフォア抗生物質による治療法やタンパク分解酵素を抗原としてDNAワクチン開発の試みは、今後の本病にの予防・治療の開発・確立に資するものである。
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