2023 Fiscal Year Final Research Report
Collective cell migration by activation wave of growth factor signal transduction cascade
| Project/Area Number |
19H00993
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 44:Biology at cellular to organismal levels, and related fields
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 康史 金沢大学, ナノ生命科学研究所, 特任教授 (90624841)
廣田 圭昭 京都大学, 医学研究科, 助教 (20852263)
平島 剛志 京都大学, 医学研究科, 講師 (10620198)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 細胞集団運動 / 創傷治癒 / 上皮細胞増殖因子 / ERKマップキナーゼ / 蛍光イメージング |
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| Outline of Final Research Achievements |
Collective cell migration is a phenomenon in which cells migrate while maintaining cell-cell adhesion, and its understanding is extremely important for understanding tissue development, wound healing, and cancer cell invasion. The applicants discovered that during the collective cell migration of epithelial cells, epidermal growth factor receptor (EGFR)-mediated activation of ERK-MAP kinase is propagated from the leader cells to the follower cells. At the beginning of this project, we addressed five questions, and we have already published papers on Aims 1, 3, and 5. Aim 2 was abandoned because the construction of the experimental system did not proceed as expected. The remaining Aim 4 has also been completed and the paper is currently being revised.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
細胞の集団運動に伴ってERKマップキナーゼの活性化が伝搬する現象は我々の発見を嚆矢とし、昆虫から哺乳動物に至るまで発見されるに至っている。申請者らは機械的刺激がこの伝搬に寄与することも明らかにしており、メカノケミカルカップリングが細胞が集団で動くときに細胞間で情報を共有するメカニズムであることを明らかにしており、多くの研究者がこの分野に参加する契機となった。また、発生異常や創傷治癒不全などの治療への手がかりを与えるものと期待される。
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