新規非侵襲的脳刺激が拓くネオ・リハビリテーションとそのシステム脳科学的解明

2020 Fiscal Year Annual Research Report

• Project/Area Number: 19H01091
• Research Institution: Ritsumeikan University
• Principal Investigator: 美馬 達哉 立命館大学, 先端総合学術研究科, 教授 (20324618)
• Co-Investigator(Kenkyū-buntansha): 小野 弓絵 明治大学, 理工学部, 専任教授 (10360207) ; 野嶌 一平 信州大学, 医学部, 准教授(特定雇用) (20646286) ; 桐本 光 広島大学, 医系科学研究科(保), 教授 (40406260) ; 松橋 眞生 京都大学, 医学研究科, 特定准教授 (40456885) ; 植木 美乃 名古屋市立大学, 医薬学総合研究院(医学), 教授 (40467478) ; 小金丸 聡子 京都大学, 医学研究科, 特定准教授 (40579059) ; 宇川 義一 福島県立医科大学, 医学部, 教授 (50168671) ; 福田 敦夫 浜松医科大学, 医学部, 教授 (50254272) ; 大須 理英子 早稲田大学, 人間科学学術院, 教授 (60374112) ; 北城 圭一 生理学研究所, システム脳科学研究領域, 教授 (70302601)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: リハビリテーション / 非侵襲的脳刺激法

Outline of Annual Research Achievements

本研究の目的は、新規非侵襲的脳刺激法（NIBS）を従来のリハと組み合わせた革新的な手法（ネオ・リハビリテーション）を開発し、その生理機構をシステム脳科学の観点から解明することである。新規NIBSとして静磁場刺激法（tSMS）とtDCSを応用したパターン電流刺激法を検討し、脳波での領域間結合測定によって脳機能ネットワークへの影響を明らかにし、動物実験による生理機構解明を目指す。静磁場刺激法（tSMS）は2011年にOlivieroらによって開発された新規NIBSであり、研究代表者らがいち早く日本に導入し、その神経可塑性効果について研究を積み重ねてきた。
研究２年目の2020年度では、静磁場刺激に関しては、健常被験者を対象に反対側半球に生じる機能促通に関連する脳機構を運動誘発電位と脳波計測によって非侵襲的に評価し、英語論文として投稿した（Takamatsu et al. 2021）。本研究でのパターン電流刺激法では、二足歩行というADL上重要な機能に着目し、自然歩行周期と同期させたパターン電流刺激を脳に与えるclosed-loop式刺激システムを開発し、内因性脳活動と外因性刺激法の間のspike-timing dependent plasticityによって歩行に関わる神経回路を可塑的に強化することを目指している。closed-loop式パターン電流刺激での歩行モジュレーションについては、筋電図コヒーレンス計測によって可塑性を解明し、論文としてまとめた（Kitatani et al. 2020）。また、小型筋電図アンプシステム（2020年度備品）を新たに購入し、さらに筋電図記録を含めた臨床研究を加速させる。新規にネオリハビリテーション目的で電気刺激装置IVES（2020年度備品）を購入して、今後add-on療法としての可能性を検討していく予定である。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

新型コロナの影響で臨床研究は一部に滞りがあったが、工夫することで、健常被験者での研究を進めることができた。全体としてはおおむね順調である。

Strategy for Future Research Activity

研究は順調に進んでおり、今後、静磁場刺激については、動物実験の結果をまとめて論文とすること、臨床研究を進めること、パターン電流刺激についても研究を加速して行く予定である。

Research Products

• [Int'l Joint Research] Hospital Nacional de Paraple’jicos(スペイン)
  • Country Name: SPAIN
  • Counterpart Institution: Hospital Nacional de Paraple’jicos
• [Int'l Joint Research] Yale School of Medicine(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Yale School of Medicine
• [Int'l Joint Research] マインツ大学(ドイツ)
  • Country Name: GERMANY
  • Counterpart Institution: マインツ大学
• [Journal Article] GABAA receptors and maternally derived taurine regulate the temporal specification of progenitors of excitatory glutamatergic neurons in the mouse developing cortex. (2021)
  • Author(s): Tochitani S, Furukawa T, Bando R, Kondo S, Ito T, Matsushima Y, Kojima T, Matsuzaki H, Fukuda A.
  • Journal Title: Cerebral Cortex Volume: 31 Pages: 4554-4575
  • DOI: 10.1093/cercor/bhab106
  • Peer Reviewed
• [Journal Article] Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human. (2021)
  • Author(s): Takamatsu Y, Koganemaru S, Watanabe T, Shibata S, Yukawa Y, Minakuchi M, Shimomura R, & Mima T
  • Journal Title: Scientific Reports Volume: 11(1) Pages: 5370
  • DOI: 10.1038/s41598-021-84823-4
  • Peer Reviewed / Open Access
• [Journal Article] ATP6V0A1 encoding the a1-subunit of the V0 domain of vacuolar H+-ATPases is essential for brain development in humans and mice. (2021)
  • Author(s): Aoto K, Kato M, Akita T, Nakashima M, Mutoh H, Akasaka N, Tohyama J, Nomura Y, Hoshino K, Ago Y, Tanaka R, Epstein O, Ben-Haim R, Heyman E, Miyazaki T, Belal H, Takabayashi S, Ohba C, Takata A, Mizuguchi T, Miyatake S, Miyake N, Fukuda A, Matsumoto N, Saitsu H.
  • Journal Title: Nature Communications Volume: 12 Pages: 2107
  • DOI: 10.1038/s41467-021-22389-5.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cortico-cortical evoked potential by single-pulse electrical stimulation is a generally safe prcedure (2021)
  • Author(s): Katsuya Kobayashi, Riki Matsumoto, Kiyohide Usami, Masao Matsuhashi, Akihiro Shimotake, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
  • Journal Title: Clinical Neurophysiology Volume: 132 Pages: 1033-1040
  • DOI: 10.1016/j.clinph.2020.12.022
  • Peer Reviewed
• [Journal Article] Appearance of bitemporal periodic EEG activity in the last stage of Gerstmann-Straussler-Scheinker syndrome (Pro102Leu): A case report (2021)
  • Author(s): Shogo Yazawa, Kazuhito Tsuruta, Akiko Sugimoto, Yukiko Suzuki, Kazuhiro Yagi, Masao Matsuhashi, Michiyoshi Yoshimura, Hiroshi Takashima
  • Journal Title: Clinical Neurophysiology Volume: 204 Pages: 106602
  • DOI: 10.1016/j.clineuro.2021.106602
  • Peer Reviewed
• [Journal Article] Transcranial direct current stimulation of the posterior parietal cortex biases human hand choice. (2021)
  • Author(s): Kento Hirayama, Takayuki Koga, Toru Takahashi, Rieko Osu
  • Journal Title: Scientific Reports Volume: 11 Pages: 204
  • DOI: 10.1038/s41598-020-80611-8
  • Peer Reviewed / Open Access
• [Journal Article] Smaller muscle mass is associated with increase in EMG?EMG coherence of the leg muscle during unipedal stance in elderly adults. (2020)
  • Author(s): Nojima I, Suwa Y, Sugiura H, Noguchi T, Tanabe S, Mima T, & Watanabe T
  • Journal Title: Human Movement Science Volume: 71 Pages: 102614
  • DOI: 10.1016/j.humov.2020.102614
  • Peer Reviewed
• [Journal Article] Entrainment of chewing rhythm by gait speed during treadmill walking in humans. (2020)
  • Author(s): Maezawa H, Koganemaru S, Matsuhashi M, Hirata M, Funahashi M, & Mima T
  • Journal Title: Neuroscience Research Volume: 156 Pages: 88-94
  • DOI: 10.1016/j.neures.2020.02.008
  • Peer Reviewed
• [Journal Article] Comparison of Phase Synchronization Measures for Identifying Stimulus-Induced Functional Connectivity in Human Magnetoencephalographic and Simulated Data. (2020)
  • Author(s): Yoshinaga K, Matsuhashi M, Mima T, Fukuyama H, Takahashi R, Hanakawa T, & Ikeda A
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 648
  • DOI: 10.3389/fnins.2020.00648
  • Peer Reviewed / Open Access
• [Journal Article] Magnification of visual feedback modulates corticomuscular and intermuscular coherences differently in young and elderly adults. (2020)
  • Author(s): Watanabe T, Nojima I, Mima T, Sugiura H, & Kirimoto H
  • Journal Title: NeuroImage Volume: 220 Pages: 117089
  • DOI: 10.1016/j.neuroimage.2020.117089
  • Peer Reviewed / Open Access
• [Journal Article] Oscillology: Nonlinear Neural Oscillations. (2020)
  • Author(s): Nambu A, Tsuda I, & Mima T
  • Journal Title: Neuroscience Research Volume: 156 Pages: 1-4
  • DOI: 10.1016/j.neures.2020.05.007
• [Journal Article] Gait-combined transcranial alternating current stimulation modulates cortical control of muscle activities during gait. (2020)
  • Author(s): Kitatani R, Koganemaru S, Maeda A, Mikami Y, Matsuhashi M, Mima T, & Yamada S
  • Journal Title: European Journal of Neuroscience Volume: 52(12) Pages: 4791-4802
  • DOI: 10.1111/ejn.14919
  • Peer Reviewed
• [Journal Article] Influence of static magnetic field stimulation on the accuracy of tachystoscopically presented line bisection. (2020)
  • Author(s): Kirimoto H, Watanabe T, Kubo N, Date S, Sunagawa T, Mima T, Ogata K, Nakazono H, Tobimatsu S, & Oliviero A
  • Journal Title: Brain Sciences Volume: 10(12) Pages: 1-14
  • DOI: 10.3390/brainsci10121006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 脳卒中片麻痺患者における反復経頭蓋磁気刺激と作業療法の併用効果―手指運動麻痺の軽度群と重度群の2群間における治療効果の差― (2020)
  • Author(s): 湯川 喜裕,中村 一仁,水口 雅俊,下村 亮太,美馬 達哉
  • Journal Title: 作業療法 Volume: 39(4) Pages: 406-413
  • DOI: 10.32178/jotr.39.4_406
  • Peer Reviewed
• [Journal Article] The effects of transcranial static magnetic fields stimulation over the supplementary motor area on anticipatory postural adjustments (2020)
  • Author(s): Tsuru D, Watanabe T, Chen X, Kubo N, Sunagawa T, Mima T, Kirimoto H
  • Journal Title: Neuroscience Letters Volume: 723 Pages: 134863
  • DOI: 10.1016/j.neulet.2020.134863
  • Peer Reviewed / Open Access
• [Journal Article] Evoked Potential as a Pain Evaluation Index for Neonatal Procedural Pain (2020)
  • Author(s): Shiroshita Y, Kirimoto H, Nakagawa K, Uematsu H, Sobue I
  • Journal Title: Journal of Nursing & Clinical Practices Volume: 7 Pages: 323
  • DOI: 10.15344/2394-4978/2020/323.
  • Peer Reviewed / Open Access
• [Journal Article] Role of beta-band resting-state functional connectivity as a predictor of motor learning ability (2020)
  • Author(s): H. Sugata, K. Yagi, S. Yazawa, Y. Nagase, K. Tsuruta, T. Ikeda, I. Nojima, M. Hara, K. Matsushita, K. Kawakami and K. Kawakami
  • Journal Title: NeuroImage Volume: 210 Pages: 116562
  • DOI: 10.1016/j.neuroimage.2020.116562
  • Peer Reviewed
• [Journal Article] Transcranial static magnetic stimulation -From bench to bedside and beyond (2020)
  • Author(s): I. Nojima, A. Oliviero and T. Mima
  • Journal Title: Neuroscience Research Volume: 156 Pages: 250-255
  • DOI: 10.1016/j.neures.2019.12.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Navigated repetitive transcranial magnetic stimulation as preoperative assessment in patients with brain tumors (2020)
  • Author(s): K. Motomura, H. Takeuchi, I. Nojima, K. Aoki, L. Chalise, K. Iijima, T. Wakabayashi and A. Natsume
  • Journal Title: Scientific Reports Volume: 10 Pages: 9044
  • DOI: 10.1038/s41598-020-65944-8
  • Peer Reviewed / Open Access
• [Journal Article] Neurobiological influence of comorbid conditions in young patients diagnosed with gaming disorder: a whole-brain functional connectivity study based on a data driven method (2020)
  • Author(s): S Kuriki, S Higuchi, H Nakayama, S Mihara, Y Okazaki, Y Ono, H Kobayashi
  • Journal Title: PLOS ONE Volume: 15 Pages: e0233780
  • DOI: 10.1371/journal.pone.0233780
  • Peer Reviewed / Open Access
• [Journal Article] Intracellular Cl- dysregulation causing and caused by pathogenic neuronal activity. (2020)
  • Author(s): Akita T, Fukuda A.
  • Journal Title: Pflugers Archiv - European Journal of Physiology Volume: 472 Pages: 977-987
  • DOI: 10.1007/s00424-020-02375-4
  • Peer Reviewed
• [Journal Article] Can we understand human brain development from experimental studies in rodents? (2020)
  • Author(s): Luhmann HJ, Fukuda A.
  • Journal Title: Pediatrics International Volume: 62 Pages: 1139-1144
  • DOI: 10.1111/ped.14339
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Iron leakage owing to blood-brain barrier disruption in small vessel disease CADASIL. (2020)
  • Author(s): Uchida Y, Kan H, Sakurai K, Arai N, Inui S, Kobayashi S, Kato D, Ueki Y, and Matsukawa N.
  • Journal Title: Neurology Volume: 95(9) Pages: e1188-e1198
  • DOI: 10.1212/WNL.0000000000010148. Epub 2020 Jun 25.
  • Peer Reviewed
• [Journal Article] Magnetic susceptibility associates with dopaminergic deficits and cognition in Parkinson’s disease. (2020)
  • Author(s): Uchida Y, Kan H, Sakurai K, Inui S, Kobayashi S, Akagawa Y, Shibuya K, Ueki Y, Matsukawa N.
  • Journal Title: Mov Disord Volume: 35(8) Pages: 1396-1405
  • DOI: 10.1002/mds.28077. Epub 2020 May 5.
  • Peer Reviewed
• [Journal Article] A proposal for new diagnostic criteria for ALS. (2020)
  • Author(s): Shefner JM, Al-Chalabi A, Baker MR, Cui LY, de Carvalho M, Eisen A, Grosskreutz J, Hardiman O, Henderson R, Matamala JM, Mitsumoto H, Paulus W, Simon N, Swash M, Talbot K, Turner MR, Ugawa Y, van den Berg LH, Verdugo R, Vucic S, Kaji R, Burke D, Kiernan MC
  • Journal Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 131 Pages: 1975-1978
  • DOI: 10.1016/j.clinph.2020.04.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Central motor conduction time reveals upper motor neuron involvement masked by lower motor neuron impairment in a significant portion of patients with amyotrophic lateral sclerosis. (2020)
  • Author(s): Tokimura R, Murakami T, Ugawa Y
  • Journal Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 131 Pages: 1896-1901
  • DOI: 10.1016/j.clinph.2020.05.021
  • Peer Reviewed
• [Journal Article] Differential effects of thyrotropin releasing hormone (TRH) on motor execution and motor adaptation process in patients with spinocerebellar degeneration. (2020)
  • Author(s): Shimizu T, Tsutsumi R, Shimizu K, Tominaga N, Nagai M, Ugawa Y, Nishiyama K, Hanajima R
  • Journal Title: Journal of the neurological sciences Volume: 415 Pages: 116927
  • DOI: 10.1016/j.jns.2020.116927
  • Peer Reviewed
• [Journal Article] Do eye movements "age" earlier in progeria? (2020)
  • Author(s): Terao Y, Matsuda SI, Ishiura H, Tsuji S, Yamamoto T, Fukuda H, Ugawa Y
  • Journal Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 131 Pages: 1835-1836
  • DOI: 10.1016/j.clinph.2020.05.019
  • Peer Reviewed
• [Journal Article] Effects of electromagnetic fields from long-term evolution on awake electroencephalogram in healthy humans. (2020)
  • Author(s): Nakatani-Enomoto S, Yamazaki M, Nishiura K, Enomoto H, Ugawa Y
  • Journal Title: Neuroscience research Volume: 156 Pages: 102-107
  • DOI: 10.1016/j.neures.2020.01.010
  • Peer Reviewed
• [Journal Article] Future of Tanscranial Magnetic Stimulation in Movement Disorders: Introduction of Novel Methods. (2020)
  • Author(s): Ugawa Y, Shimo Y, Terao Y
  • Journal Title: Journal of movement disorders Volume: 13 Pages: 115-117
  • DOI: 10.14802/jmd.19083
  • Peer Reviewed
• [Journal Article] TMS activation site estimation using multiscale realistic head models (2020)
  • Author(s): Gomez-Tames J., Laakso I., Murakami T., Ugawa Y., Hirata A.
  • Journal Title: Journal of Neural Engineering Volume: 17 Pages: 36004
  • DOI: 10.1088/1741-2552/ab8ccf
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Triad TMS of the human motor cortex. (2020)
  • Author(s): Hanajima R, Ugawa Y
  • Journal Title: Neuroscience research Volume: 156 Pages: 245-249
  • DOI: 10.1016/j.neures.2019.11.005
  • Peer Reviewed
• [Journal Article] Voluntary and involuntary movements: A proposal from a clinician. (2020)
  • Author(s): Ugawa Y
  • Journal Title: Neuroscience research Volume: 156 Pages: 80-87
  • DOI: 10.1016/j.neures.2019.10.001
  • Peer Reviewed
• [Journal Article] World Congress of Neurology 2019, WCN2019（WCN 2019）に参加して (2020)
  • Author(s): 宇川 義一
  • Journal Title: 神経治療学 Volume: 37 Pages: 53-54
  • DOI: 10.15082/jsnt.37.1_53
  • Peer Reviewed
• [Journal Article] Possible role of backpropagating action potentials in corticospinal neurons in I-wave periodicity following a TMS pulse. (2020)
  • Author(s): Ugawa Y, Rothwell JC, Paulus W
  • Journal Title: Neuroscience research Volume: 156 Pages: 234-236
  • DOI: 10.1016/j.neures.2019.10.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quadripulse stimulation (QPS). (2020)
  • Author(s): Matsumoto H, Ugawa Y
  • Journal Title: Experimental brain research Volume: 238 Pages: 1619-1625
  • DOI: 10.1007/s00221-020-05788-w
  • Peer Reviewed
• [Journal Article] TMS Intervention of Human Neuronal Network (2020)
  • Author(s): Ugawa Y
  • Journal Title: Brain and nerve Volume: 72(11) Pages: 1239-1246
  • DOI: 10.11477/mf.1416201675
  • Peer Reviewed
• [Journal Article] Direct comparison of efficacy of the motor cortical plasticity induction and the interindividual variability between TBS and QPS. (2020)
  • Author(s): Tiksnadi A, Murakami T, Wiratman W, Matsumoto H, Ugawa Y
  • Journal Title: Brain stimulation Volume: 13 Pages: 1824-1833
  • DOI: 10.1016/j.brs.2020.10.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Idiopathic hypereosinophilic syndrome with formation of multiple liver mass lesions (2020)
  • Author(s): Ko Tetsuhisa, Fujii Hideki, Doi Haruna, Fukuma Taito, Kadono Toru, Asaeda Kohei, Kobayashi Reo, Nakano Takahiro, Doi Toshifumi, Nakatsugawa Yoshikazu, Yamada Shinya, Nishimura Takeshi, Tomatsuri Naoya, Sato Hideki, Okuyama Yusuke, Kimura Hiroyuki, Yoshida Norimasa
  • Journal Title: Clinical Journal of Gastroenterology Volume: 13 Pages: 834-838
  • DOI: 10.1007/s12328-020-01113-8
  • Peer Reviewed
• [Journal Article] Prominent Prolongation of Cortical Silent Period Induced by Transcranial Magnetic Stimulation in Creutzfeldt-Jakob Disease. (2020)
  • Author(s): Matsumoto H, Uchio N, Hao A, Haga M, Abe C, Sakamoto Y, Ugawa Y
  • Journal Title: Case reports in neurology Volume: 12 Pages: 447-541
  • DOI: 10.1159/000510395
  • Peer Reviewed / Open Access
• [Journal Article] Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines (2020)
  • Author(s): Rossi S.,,,,, Ugawa Y., Wassermann E.M., Zangen A., Ziemann U., Hallett M.
  • Journal Title: Clinical Neurophysiology Volume: 132(1) Pages: 269-306
  • DOI: 10.1016/j.clinph.2020.10.003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Training in the practice of noninvasive brain stimulation: Recommendations from an IFCN committee. (2020)
  • Author(s): Fried PJ, Santarnecchi E, Antal A, Bartres-Faz D, Bestmann S, Carpenter LL, Celnik P, Edwards D, Farzan F, Fecteau S, George MS, He B, Kim YH, Leocani L, Lisanby SH, Loo C, Luber B, Nitsche MA, Paulus W, Rossi S, Rossini PM, Rothwell J, Sack AT, Thut G, Ugawa Y, Ziemann U, Hallett M, Pascual-Leone A
  • Journal Title: Clinical Neurophysiology Volume: 132(3) Pages: 819-837
  • DOI: 10.1016/j.clinph.2020.11.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Scalp EEG Could Record Both Ictal Direct Current Shift and High-Frequency Oscillation Together Even With a Time Constant of 2 Seconds (2020)
  • Author(s): Tomohiko Murai, Takefumi Hitomi, Masao Matsuhashi, Riki Matsumoto, Yuki Kawamura, Masutaro Kanda, Ryosuke Takahashi, Akio Ikeda
  • Journal Title: Journal of Clinical Neurophysiology Volume: 37 Pages: 191-194
  • DOI: 10.1097/WNP.0000000000000670
  • Peer Reviewed
• [Journal Article] Effects of a stable concentration of propofol upon interictal high-frequency oscillations in drug-resistant epilepsy (2020)
  • Author(s): Taku Inada, Katsuya Kobayashi, Takayuki Kikuchi, Masao Matsuhashi, Riki Matsumoto, Yuki Takahashi, Takuro Nakae, Sumiya Shibata, Yukihiro Yamao, Masako Daifu, Jumpei Togawa, Kazumichi Yoshida, Takeharu Kunieda, Kobayashi K, Akio Ikeda, Susumu Miyamoto
  • Journal Title: Epileptic Disord Volume: 23 Pages: 299-312
  • DOI: 10.1684/epd.2021.1264
  • Peer Reviewed / Open Access
• [Journal Article] Engagement of cortico-cortical and cortico-subcortical networks in a patient with epileptic spasms: An integrated neurophysiological study (2020)
  • Author(s): Takeshi Inoue, Katsuya Kobayashi, Riki Matsumoto, Morito Inouchi, Masaya Togo, Jumpei Togawa, Kiyohide Usami, Akihiro Shimotake, Masao Matsuhashi, Takayuki Kikuchi, Kazumichi Yoshida, Hisashi Kawawaki, Nobukatsu Sawamoto, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Akio Ikeda
  • Journal Title: Clinical Neurophysiology Volume: 131 Pages: 2255-2264
  • DOI: 10.1016/j.clinph.2020.04.167
• [Journal Article] Electrical Cortical Stimulations Modulate Spike and Post-Spike Slow-Related High-Frequency Activities in Human Epileptic Foci (2020)
  • Author(s): Mitsuyoshi Nakatani, Riki Matsumoto, Katsuya Kobayashi, Takefumi Hitomi, Morito Inouchi, Masao Matsuhashi, Masako Kinoshita, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, Susumu Miyamoto, Ryosuke Takahashi, Nobutaka Hattori, Akio Ikeda
  • Journal Title: Clinical Neurophysiology Volume: 131 Pages: 1741-1754
  • DOI: 10.1016/j.clinph.2020.03.042
• [Journal Article] Connectivity Gradient in the Human Left Inferior Frontal Gyrus: Intraoperative Cortico-Cortical Evoked Potential Study (2020)
  • Author(s): Takuro Nakae, Riki Matsumoto, Takeharu Kunieda, Yoshiki Arakawa, Katsuya Kobayashi, Akihiro Shimotake, Yukihiro Yamao, Takayuki Kikuchi, Toshihiko Aso, Masao Matsuhashi, Kazumichi Yoshida, Akio Ikeda, Ryosuke Takahashi, Matthew A Lambon Ralph, Susumu Miyamoto
  • Journal Title: Cerebral Cortex Volume: 30 Pages: 4633-4650
  • DOI: 10.1093/cercor/bhaa065
• [Journal Article] Pattern Recognition in Epileptic EEG Signals via Dynamic Mode Decomposition (2020)
  • Author(s): Jong-Hyeon Seo, Ichiro Tsuda, Young Ju Lee, Akio Ikeda, Masao Matsuhashi, Riki Matsumoto, Takayuki Kikuchi, Hunseok Kang
  • Journal Title: Mathematics Volume: 8 Pages: 481
  • DOI: 10.3390/math8040481
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Timing of the Sense of Volition in Patients With Schizophrenia (2020)
  • Author(s): Sarah Pirio Richardson, Antonio I Triggiani, Masao Matsuhashi, Valerie Voon, Elizabeth Peckham, Fatta Nahab, Zoltan Mari, Mark Hallett
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 574472
  • DOI: 10.3389/fnins.2020.574472
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cortical Distribution of Fragile Periventricular Anastomotic Collateral Vessels in Moyamoya Disease: An Exploratory Cross-Sectional Study of Japanese Patients with Moyamoya Disease (2020)
  • Author(s): Akinori Miyakoshi, Takeshi Funaki, Yasutaka Fushimi, Takuro Nakae, Masakazu Okawa, Takayuki Kikuchi, Hiroharu Kataoka, Kazumichi Yoshida, Yohei Mineharu, Masao Matsuhashi, Eiji Nakatani, Susumu Miyamoto
  • Journal Title: AJNR Am J Neuroradiol Volume: 41 Pages: 2243-2249
  • DOI: 10.3174/ajnr.A6861
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal correspondence of epilepsy and scalp EEG fast (40-200 Hz) oscillations in pediatric patients with tuberous sclerosis complex (2020)
  • Author(s): Hiroki Tsuchiya, Fumika Endoh, Tomoyuki Akiyama, Masao Matsuhashi, Katsuhiro Kobayashi
  • Journal Title: Brain Dev Volume: 42 Pages: 663-674
  • DOI: 10.1016/j.braindev.2020.06.001
  • Peer Reviewed
• [Journal Article] Cerebellar transcranial alternating current stimulation modulates human gait rhythm (2020)
  • Author(s): Satoko Koganemaru, Yusuke Mikami, Masao Matsuhashi, Dennis Q Truong, Marom Bikson, Kenji Kansaku, Tatsuya Mima
  • Journal Title: Neuroscience research Volume: 156 Pages: 265-270
  • DOI: 10.1016/j.neures.2019.12.003
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gait-synchronized oscillatory brain stimulation modulates common neural drives to ankle muscles in patients after stroke: A pilot study (2020)
  • Author(s): Ryosuke Kitatani, Satoko Koganemaru, Ayaka Maeda, Yusuke Mikami, Masao Matsuhashi, Tatsuya Mima, Shigehito Yamada
  • Journal Title: Neuroscience research Volume: 156 Pages: 256-264
  • DOI: 10.1016/j.neures.2019.11.001
  • Peer Reviewed
• [Journal Article] Active direct current (DC) shifts and "Red slow": two new concepts for seizure mechanisms and identification of the epileptogenic zone (2020)
  • Author(s): Akio Ikeda, Hirofumi Takeyama, Christophe Bernard, Mitsuyoshi Nakatani, Akihiro Shimotake, Masako Daifu, Masao Matsuhashi, Takayuki Kikuchi, Takeharu Kunieda, Riki Matsumoto, Tamaki Kobayashi, Kazuaki Sato
  • Journal Title: Neuroscience research Volume: 156 Pages: 95-101
  • DOI: 10.1016/j.neures.2020.01.014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mathematical structures for epilepsy: High-frequency oscillation and interictal epileptic slow (red slow) (2020)
  • Author(s): Takao Namiki, Ichiro Tsuda, Satoru Tadokoro, Shunsuke Kajikawa, Takeharu Kunieda, Riki Matsumoto, Masao Matsuhashi, Akio Ikeda
  • Journal Title: Neuroscience research Volume: 156 Pages: 178-187
  • DOI: 10.1016/j.neures.2019.11.008
  • Peer Reviewed
• [Journal Article] ヒトの発振操作による動的ネットワークの制御と臨床応用 . (2020)
  • Author(s): 小金丸 聡子,神作 憲二,美馬 達哉
  • Journal Title: Brain Nerve. Volume: 72 Pages: 1223-1237
  • DOI: 10.11477/mf.1416201674.
• [Journal Article] 脳卒中後上肢機能障害における非侵襲的中枢神経刺激療法 (rTMS,tDCS) の効果と至適刺激条件―近年のメタ解析より― (2020)
  • Author(s): 小金丸 聡子
  • Journal Title: The Japanese Journal of Rehabilitation Medicine Volume: 57 Pages: 792-798
  • DOI: 10.2490/jjrmc.57.792
• [Presentation] Voltage-sensitive Na+ and K+ current components in interneuron precursors in the medial ganglionic eminence of the embryonic cerebrum. (2021)
  • Author(s): 秋田天平, 福田敦夫.
  • Organizer: 第126回日本解剖学会総会,全国学術集会,第98回日本生理学会大会
• [Presentation] Developmentally regulated KCC2 phosphorylation is critical for dynamic GABA-mediated inhibition. (2021)
  • Author(s): 渡部美穂, Kahle KT, Fukuda A.
  • Organizer: 第126回日本解剖学会総会,全国学術集会,第98回日本生理学会大会
• [Presentation] 胎児期,生後発達期のタウリン枯渇は大脳皮質錐体神経の発火応答を鈍麻させる. (2021)
  • Author(s): 秋田天平, 細井泰志, 渡部美穂, 伊藤崇志, 宮嶋裕明, 福田敦夫.
  • Organizer: 第7回国際タウリン研究会日本部会学術集会
• [Presentation] 神経細胞内タウリンによるリン酸化を介したGABAA受容体発現制御機構. (2021)
  • Author(s): 渡部美穂, 細井泰志, 秋田天平, 伊藤崇志, 福田敦夫.
  • Organizer: 第7回国際タウリン研究会日本部会学術集会
• [Presentation] 発達期皮質錐体細胞におけるCa2+動態とタウリンによるGABAA受容体活性化. (2021)
  • Author(s): 石橋賢, 阪東勇輝, 佐藤康二, 福田敦夫.
  • Organizer: 第7回国際タウリン研究会日本部会学術集会
• [Presentation] Event-related desynchronization during swallowing in healthy adults. (2021)
  • Author(s): Satoko Koganemaru, Fumiya Mizuno, Toshimitsu Takahashi, Yuu Takemura, Hiroshi Irisawa, Masao Matsuhashi, Tatsuya Mima, Takashi Mizushima, Kenji Kansaku
  • Organizer: 第98回日本生理学会大会
• [Presentation] A new noninvasive closed-loop system for gait-synchronized brain stimulation applied for stroke rehabilitation (2020)
  • Author(s): Tatsuya Mima
  • Organizer: 第43回日本神経科学大会
• [Presentation] Central mechanisms of tongue motor functions in humans (2020)
  • Author(s): Hitoshi Maezawa,Tatsuya Mima,Michael A Nitsche,Masayuki Hirata
  • Organizer: 第43回日本神経科学大会
• [Presentation] Simulation Study for the magnetic field distribution produced by the brand-new transcranial static magnetic stimulation with three magnets (2020)
  • Author(s): Sumiya Shibata,Jianxu Zhang,Hen Wang,Jinglong Wu,Tatsuya Mima
  • Organizer: 第43回日本神経科学大会
• [Presentation] 脳卒中後慢性疼痛に対する経頭蓋直流電気刺激の使用経験 (2020)
  • Author(s): 佐藤岳史,江藤謹司,美馬達哉
  • Organizer: 第57回日本リハビリテーション医学会学術集会
• [Presentation] 右下部頭頂葉梗塞にて軽度の失行を呈した症例における道具操作課題とtDCS効果 (2020)
  • Author(s): 小金丸聡子,石橋遼,冨岡正雄,美馬達哉,佐浦隆一
  • Organizer: 第57回日本リハビリテーション医学会学術集会
• [Presentation] Recent Topics in Neuromodulation by transcranial Static Magnetic Stimulation (2020)
  • Author(s): Tatsuya Mima
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] 治療的側面からみたてんかん発作と発作性運動異常症の違い (2020)
  • Author(s): 美馬達哉
  • Organizer: 第61回日本神経学会学術大会
• [Presentation] Transcranial static magnetic field stimulation over the supplementary motor area modulates function of anticipatory postural adjustments (2020)
  • Author(s): Kuwabara T, Watanabe T, Matsumoto T, Yunoki K, Kubo N, Chen X, Mima T, Kirimoto H
  • Organizer: Federation of European neuroscience society (Web)
  • Int'l Joint Research
• [Presentation] Excitability of the ipsilateral primary motor cortex during unilateral finger movment: the effect of hand dominance (2020)
  • Author(s): Matsumoto T, Watanabe T, Kuwabara T, Yunoki K, Chen X, Kubo N, Kirimoto H
  • Organizer: Federation of European neuroscience society (Web)
  • Int'l Joint Research
• [Presentation] Greater amount of visual information increases corticomuscular coherence in elderly but not in young adults (2020)
  • Author(s): Watanabe T, Matsumoto T, Yunoki K, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
  • Organizer: Federation of European neuroscience society (Web)
  • Int'l Joint Research
• [Presentation] Transcranial static magnetic stimulation over the temporal lobe induces plastic changes in the accuracy of tachystoscopically presented line bisection (2020)
  • Author(s): Yunoki K, Watanabe T, Matsumoto T, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
  • Organizer: Federation of European neuroscience society (Web)
  • Int'l Joint Research
• [Presentation] The effects of transcranial static magnetic field stimulation over the supplementary motor area on the function of anticipatory postural adjustments (2020)
  • Author(s): Kuwabara T, Watanabe T, Matsumoto T, Yunoki K, Kubo N, Chen X, Mima T, Kirimoto H
  • Organizer: 14th ICME International Conference on Complex Medical Engineering (Web)
  • Int'l Joint Research
• [Presentation] Laterality of intracortical inhibition in the ipsilateral primary motor cortex during unilateral finger movement (2020)
  • Author(s): Matsumoto T, Watanabe T, Kuwabara T, Yunoki K, Chen X, Kubo N, Kirimoto H
  • Organizer: 14th ICME International Conference on Complex Medical Engineering (Web)
  • Int'l Joint Research
• [Presentation] Changes in corticomuscular and intermuscular coherences associated with visuomotor control (2020)
  • Author(s): Watanabe T, Matsumoto T, Yunoki K, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
  • Organizer: 14th ICME International Conference on Complex Medical Engineering (Web)
  • Int'l Joint Research
• [Presentation] The effects of transcranial static magnetic field stimulation on the accuracy of tachystoscopically presented line bisection (2020)
  • Author(s): Yunoki K, Watanabe T, Matsumoto T, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
  • Organizer: 14th ICME International Conference on Complex Medical Engineering (Web)
  • Int'l Joint Research
• [Presentation] 静磁場刺激の臨床応用への可能性 ，ワークショップ「経頭蓋電気刺激と脳深部刺激の現状と課題」 (2020)
  • Author(s): 桐本 光
  • Organizer: 日本臨床神経生理学会学術大会第50回記念大会（京都）
  • Invited
• [Presentation] 企画セミナ「片麻痺患者に対する機能訓練と非侵襲的脳刺激との併用における現状と今後の可能性」 (2020)
  • Author(s): 桐本 光
  • Organizer: 第54回日本作業療法学会(Web)
  • Invited
• [Presentation] 一側手指運動時の同側一次運動野内における皮質内抑制機能の変化とそのラテラリティ (2020)
  • Author(s): 松本 卓也，渡邊 龍憲，桑原 貴之，柚木 啓輔，陳 瀟瀟，久保 南実，桐本 光
  • Organizer: 第75回日本体力医学会大会(Web)
• [Presentation] 若年者と高齢者における視覚運動制御と脳波筋電図間コヒーレンスの関連． (2020)
  • Author(s): 渡邊 龍憲，松本卓也，柚木啓輔，陳 瀟瀟，久保 南実，桑原 貴之，桐本 光
  • Organizer: 第75回日本体力医学会大会(Web)
• [Presentation] 異なる動作課題間における予測性姿勢調節機能の関係性 (2020)
  • Author(s): 石田 晴輝，渡邊 龍憲，桑原 貴之，久保 南実，松本 卓也，柚木 啓輔，陳 瀟瀟，伊藤 佳奈実，桐本 光
  • Organizer: 日本臨床神経生理学会学術大会第50回記念大会（京都）
• [Presentation] 視覚情報の有無がBimanual load-lifting task時の予測性姿勢調節に及ぼす影響 (2020)
  • Author(s): 桑原 貴之，田村 優衣 ，久保 南実，松本 卓也，陳 瀟瀟，柚木 啓輔，渡邊 龍憲，桐本 光
  • Organizer: 日本臨床神経生理学会学術大会第50回記念大会（京都）
• [Presentation] 中前頭theta律動と後頭gamma律動は視覚運動制御に関連する (2020)
  • Author(s): 渡邊 龍憲，松本卓也，柚木啓輔，陳 瀟瀟，久保 南実，桑原 貴之，桐本 光
  • Organizer: 日本臨床神経生理学会学術大会第50回記念大会（京都）
• [Presentation] Bimanual load-lifting課題時の視覚情報が予測性姿勢調節機能に及ぼす影響 (2020)
  • Author(s): 桑原 貴之，田村 優衣 ，久保 南実，松本 卓也，陳 瀟瀟，柚木 啓輔，渡邊 龍憲，桐本 光
  • Organizer: 第14回日本作業療法研究学会学術大会（Web）
• [Presentation] 異なる動作課題間における予測性姿勢調節機能の関係性 (2020)
  • Author(s): 石田 晴輝，渡邊 龍憲，桑原 貴之，久保 南実，松本 卓也，柚木 啓輔，陳 瀟瀟，伊藤 佳奈実，桐本 光
  • Organizer: 第14回日本作業療法研究学会学術大会（Web）
• [Presentation] 視覚刺激色のストループ効果色のイメージがGo/NoG-go課題の反応時間と事象関連電位に与える影響の検討 (2020)
  • Author(s): 久保 南実，石田 晴輝，渡邊 龍憲，桑原 貴之，松本 卓也，柚木 啓輔，陳 瀟瀟，伊藤 佳奈実，桐本 光
  • Organizer: 第14回日本作業療法研究学会学術大会（Web）
• [Presentation] ミラー療法による運動麻痺へのアプローチ (2020)
  • Author(s): 野嶌一平
  • Organizer: 第50回日本臨床神経生理学会学術大会
• [Presentation] EEG Classification of Grasp and Pinch Movements by Transfer Learning of Image-based CNN (2020)
  • Author(s): M Hoshino, Y Ono
  • Organizer: The 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC2020)
  • Int'l Joint Research
• [Presentation] Detection of tissue metabolic rate of oxygen: a combined near-infrared spectroscopy and diffuse correlation spectroscopy study (2020)
  • Author(s): Y Ono, M Nakabayashi, M Kono, M Ichinose
  • Organizer: CME2020
  • Int'l Joint Research / Invited
• [Presentation] Functional recovery and brain network changes in stroke motor rehabilitation using brain machine interface (2020)
  • Author(s): Y. Ono
  • Organizer: International Joint Meeting 2020 in Kansai
  • Int'l Joint Research / Invited
• [Presentation] Brain machine interface for personalized stroke motor rehabilitation (2020)
  • Author(s): Y. Ono
  • Organizer: International Conference on Mathematical Modeling and Applications (ICMMA 2020)
  • Int'l Joint Research / Invited
• [Presentation] 脳卒中リハビリテーション前後の運動野半球間結合性の変化と機能回復との関連 (2020)
  • Author(s): 森明子，小野弓絵，伊藤麻帆，水口茉理菜，河野正志，富永孝紀
  • Organizer: 第59回 日本生体医工学会大会
• [Presentation] 多感覚フィードバックを付与する家庭内自由歩行訓練用VRの開発 (2020)
  • Author(s): 永嶋 裕也, 伊藤 大剛, 小倉 亮, 富永 孝紀, 小野 弓絵
  • Organizer: 第59回 日本生体医工学会大会
• [Presentation] 安静時μ波強度に着目した運動想起脳活動の検出方法の検討 (2020)
  • Author(s): 中禮周，小野弓絵
  • Organizer: 第59回 日本生体医工学会大会
• [Presentation] Brain-Machine Interfaceを用いたDigital Mirror Boxによる神経リハビリテーション:-システム改良後の臨床効果- (2020)
  • Author(s): 藤原揺平，寺田萌，河野正志，市村幸盛，小野弓絵
  • Organizer: 第54回日本作業療法学会
• [Presentation] 最適な極性の経頭蓋直流電気刺激が運動想起時脳活動に与える効果の検討 (2020)
  • Author(s): 飯尾 恵俊, 美馬 達哉, 小野 弓絵
  • Organizer: 第98回日本生理学会大会
• [Presentation] 神経連続発火活動低下を伴うてんかん性脳症発症機序の解明を目指して. (2020)
  • Author(s): 秋田天平, 青戸一司, 才津浩智, 北野勝則, 福田敦夫.
  • Organizer: 第47回日本脳科学会
• [Presentation] 背側縫線核セロトニン作動性ニューロンにおけるオレキシン誘発性発火後過分極がシナプス入力感受性に及ぼす影響. (2020)
  • Author(s): 石橋賢, 福田敦夫, Leonard CS.
  • Organizer: 第47回日本脳科学会
• [Presentation] リン酸化によるカリウム-クロライド共輸送体(KCC2)の機能制御はGABAによる抑制性伝達形成に必須である. (2020)
  • Author(s): 渡部美穂, Kahle KT, 福田敦夫.
  • Organizer: 第47回日本脳科学会
• [Presentation] Gad1ヘテロ欠損と胎生期ストレスの二重ヒットによりエピジェネティックに惹起される神経発生,分化の運命転化. (2020)
  • Author(s): 王天英, Sinha AS, 柳川右千夫, 河合智子, 秦健一郎, 福田敦夫.
  • Organizer: 第47回日本脳科学会
• [Presentation] Prenatal stress on Gad1 insufficient fetuses enhances tonic inhibition in medial prefrontal cortex by increasing excitability of GABA neurons. (2020)
  • Author(s): Fukuda A, Wang T, Sinha AS, Akita T, Yanagawa Y.
  • Organizer: The 23rd Annual Meeting of the Korean Society for Brain and Neural Sciences (KSBNS)
  • Int'l Joint Research
• [Presentation] 胎生脳内側基底核原基の神経前駆細胞における２種類の電位依存性陽イオン電流の発見. (2020)
  • Author(s): 秋田天平, 福田敦夫.
  • Organizer: 第67回中部日本生理学会
• [Presentation] カリウム-クロライド共役担体(KCC2)のリン酸化による機能制御. (2020)
  • Author(s): 渡部美穂, Kahle KT, 福田敦夫.
  • Organizer: 第67回中部日本生理学会
• [Presentation] 発達期皮質錐体細胞におけるCa2+動態とタウリンによるGABAA受容体活性化. (2020)
  • Author(s): 石橋賢，阪東勇輝, 佐藤康二, 福田敦夫.
  • Organizer: 第67回中部日本生理学会
• [Presentation] Identification of the GABAergic projections from arcuate nucleus involved in modulation of the CRH release. (2020)
  • Author(s): Yesmin R, Watanabe M, Wang T, Sinha AS, Akita T, Ishibashi M, Fukuda A.
  • Organizer: 第67回中部日本生理学会
• [Presentation] Gad1 heterozygotes subjected to prenatal stress undergo epigenetic dysregulation of genes perturbing neurodevelopment and behavior. (2020)
  • Author(s): Sinha AS, Wang T, Mutoh H, Akita T, Yanagawa Y, Kawai T, Hata K, Fukuda A.
  • Organizer: 第67回中部日本生理学会
• [Presentation] Prenatal stress on Gad1 insufficient fetuses drastically change GABA transmission in the medial prefrontal cortex. (2020)
  • Author(s): Fukuda A.
  • Organizer: KSBMB International Conference 2020
  • Int'l Joint Research
• [Presentation] Pivotal roles of neuronal excitation-inhibition dynamics in epileptogenesis of human and animal models. (2020)
  • Author(s): Fukuda A.
  • Organizer: The 21st Annual Meeting of the Infantile Seizure Society (ISS)
  • Int'l Joint Research / Invited
• [Presentation] TMS-EEG計測による脳ダイナミクスのプローブ手法の提案. (2020)
  • Author(s): 北城圭一
  • Organizer: 日本臨床神経生理学会学術大会 第50回記念大会
  • Invited
• [Presentation] Clinical Application of tSMS in Stroke. (2020)
  • Author(s): Koganemaru Satoko
  • Organizer: 7th International Conference on Non-Invasive Brain Stimulation
  • Int'l Joint Research / Invited
• [Presentation] 脳波による嚥下関連脳活動―健常人における検討. (2020)
  • Author(s): 小金丸 聡子, 武村 優, 入澤 寛, 美馬 達哉,美津島 隆, 神作 憲司.
  • Organizer: 第４回日本リハビリテーション医学会秋季学術集会