2023 Fiscal Year Final Research Report
Understanding of the retinal functional organization for spatio-temporal visual information processing by a simulation model
| Project/Area Number |
19H01140
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 62:Applied informatics and related fields
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
立花 政夫 立命館大学, 総合科学技術研究機構, 教授 (60132734)
小池 千恵子 立命館大学, 薬学部, 教授 (80342723)
川村 晃久 立命館大学, 生命科学部, 教授 (90393199)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 網膜 / 網膜色素変性症 / 神経回路モデル |
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| Outline of Final Research Achievements |
Retinitis pigmentosa is a representative disease of the retina, which eventually leads to blindness. The therapy of this disease has not yet been developed. Regenerative medicine and other therapies have been being developed, but their effectiveness depends on the condition of the patient's retina. Studies on animal models of the disease have shown that abnormal autonomic neural activity is observed in the diseased retina. In order to understand the patient retinal condition, we clarified the mechanism of the abnormal autonomic neural activity by which the diseased neural activity occurs by means of electro-physiological experiments, histological analysis, and mathematical model simulations.
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| Free Research Field |
計算論的神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
網膜色素変性症の治療には、その疾患により脱落する視細胞を再生技術により再生した視細胞の移植により補填することが試みられているが、その効果は視細胞の下流にあたる網膜神経の状態に依存する。本研究により、２次変性部位と病変神経活動の原因がその変性であることを明らかにできたので、治療のターゲットを同定できることにより、より確実な治療法の開発に寄与すると期待できる。
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