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2022 Fiscal Year Final Research Report

Food functional research for human application of cancer inhibitory ingredients contained in heirloom vegetables in Kyoto

Research Project

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Project/Area Number 19H01610
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionKyoto Prefectural University

Principal Investigator

NAKAMURA YASUSHI  京都府立大学, 文学部, 教授 (90285247)

Co-Investigator(Kenkyū-buntansha) 今井 俊夫  国立研究開発法人国立がん研究センター, 研究所, 施設長 (20342884)
岡本 繁久  鹿児島大学, 農水産獣医学域農学系, 准教授 (30211808)
佐々木 梓沙  京都府立大学, 生命環境科学研究科, 助手 (90761966)
Project Period (FY) 2019-04-01 – 2023-03-31
Keywords食品機能性 / 京野菜 / 桂ウリ / 含硫化合物 / 乳がん / 大腸がん
Outline of Final Research Achievements

MTAE, a fragrant component of Katsura-uri (heirloom vegetables in Kyoto), undergoes a chemical change in our body and is converted into MTA, which exhibits cancer chemopreventive effect. We focused on MTA and performed carcinogenesis inhibition test using animals and molecular biological test using human colon cancer cells. From this study, we obtained data suggesting that the cancer chemopreventive effect of MTA differs depending on the mode of carcinogenesis and organs, and that it suppresses the expression of multiple genes involved in carcinogenesis.

Free Research Field

食品科学

Academic Significance and Societal Importance of the Research Achievements

超長寿社会となった国で直面している世界的な課題であるがんについて,本研究を実施することで,日本の伝統野菜のひとつである京野菜の桂ウリに含まれる香りの成分がもつ発がん抑制の効果としくみを明らかにする手がかりを得ました.将来,本研究の成果を発展させれば,超長寿社会の国において健康寿命を延伸する和食材のひとつである桂ウリを活用したり,発がん抑制のしくみを利用した新たな薬品開発の指標に活用したりする応用が期待できます.

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Published: 2024-01-30  

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