Luminescence of carbon nanotube-enzyme complex and its application

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H02539
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 28010:Nanometer-scale chemistry-related
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Takaka Takeshi 国立研究開発法人産業技術総合研究所, 材料・化学領域, 研究グループ長 (30415707)
• Co-Investigator(Kenkyū-buntansha): 片浦 弘道 国立研究開発法人産業技術総合研究所, 材料・化学領域, 招聘研究員 (30194757) ; 平塚 淳典 国立研究開発法人産業技術総合研究所, 材料・化学領域, 研究グループ長 (70392652)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: カーボンナノチューブ / 酵素 / 発光 / 近赤外光

Outline of Final Research Achievements

Research on near-infrared emission of carbon nanotubes by enzymatic reactions was conducted. Near-infrared light has high transparency and low scattering property for living tissues and is very suitable for medical applications, but when fluorescence is used, there are problems of low permeability of the excitation light and autofluorescence derived from biomolecules. Since the emission of carbon nanotubes by the enzymatic reaction in this study does not require external excitation light, it is possible to avoid these problems. In this study near infrared emission from carbon nanotubes by enzymatic reaction from firefly (luciferase). It was confirmed that the emission wavelengths corresponded to the structures of multiple types of carbon nanotubes. Further, improvement for the efficiency of light emission is going on.

Free Research Field

ナノ材料科学

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた成果は、酵素反応の発光を用いることで、外部からの励起光なしに、生体組織の透過性の高い近赤外光をカーボンナノチューブから発することを可能とするものである。この様な報告はこれまでになく、学術的に重要なだけでなく、新たな診断法などの新規用途の開発にも繋がる、社会的意義も有するものである。