Photochemistry and application of "molecularly encapsulated dyes" shielded from outside using rotaxane formation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H02699
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 33010:Structural organic chemistry and physical organic chemistry-related
• Research Institution: University of Toyama
• Principal Investigator: Inouye Masahiko 富山大学, 大学本部, 理事・副学長 (60211752)
• Co-Investigator(Kenkyū-buntansha): 大石 雄基 富山大学, 学術研究部薬学・和漢系, 助教 (00778467)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ロタキサン / シクロデキストリン / バイオプローブ / 円偏光発光 / フォトクロミック材料

Outline of Final Research Achievements

Rotaxane-type dyes with pi-conjugated molecules encapsulated within cyclodextrins exhibit unique photophysical properties such as solvent-independent quantum yield, extremely high light-tolerance, and concentration-independent excimer emission because a specific number of molecules are shielded from the external environment by encapsulation of cyclodextrins. In this study, we have succeeded in the high-yield synthesis of dyes suitable for single-molecule imaging and circularly polarized luminescent molecules with a wide variety of color variations by using the template-directed click strategy.

Free Research Field

構造有機化学

Academic Significance and Societal Importance of the Research Achievements

今回合成したロタキサン型色素の設計は，外部環境から“防弾ガラス”で保護された孤立空間内に，特定数の蛍光分子を封止できる。この種の“分子封止型色素”は特色ある光物性が予見されていたものの，合成の難しさ等の理由から報告例は未だに少なかった。本申請研究では，ロタキサン型蛍光色素の汎用性の高い合成法を開拓し，有用なロタキサン型色素群の創製することで“分子封止型色素”の学術の確立に貢献できた。