2023 Fiscal Year Final Research Report
Development of New Reaction Processes Involving Direct and Stereoselective Addition of C-H Bonds
| Project/Area Number |
19H02721
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 33020:Synthetic organic chemistry-related
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| Research Institution | Osaka Metropolitan University (2022-2023)
Osaka City University (2019-2021) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 不斉合成 / 触媒 / 有機合成 / 立体選択的反応 / 遷移金属 / アルケン / 芳香族化合物 |
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| Outline of Final Research Achievements |
We have developed following atom-economical organic transformations by using transition-metal-catalysts, which include stereoselective addition of C-H to carbon-carbon unsaturated bonds: 1) Asymmetric addition reactions of aromatic C-H bonds, 2) Asymmetric alkylation of sp3 C-H bonds, 3) Cyclization reactions using sequential alkylation of C-H bonds, 4) Alkylation and allylation of sp2 C-H bonds, 5) Rhodium-catalyzed asymmetric arylation, 6) Iridium-catalyzed asymmetric cyclization and asymmetric addition of imides, 7) Transformation of sugar derivatives using transfer hydrogenation catalysts.
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| Free Research Field |
有機化学
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| Academic Significance and Societal Importance of the Research Achievements |
遷移金属触媒を用いた不飽和結合へのC-H結合の付加反応は，無駄となる原子のない高原子効率型反応であり，その開発は有用な有機化合物合成プロセスに必要不可欠である．本研究で開発された反応は，様々な炭素骨格を立体選択的に構築する新しい手法である．不斉付加反応にも成功しており，生理活性物質や天然物など幅広い化合物の効率的な合成にも応用できる可能性を持つ．
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