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2021 Fiscal Year Final Research Report

Molecular mechanisms of bioprobes targeting inflammatory reaction and hypoxic respose

Research Project

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Project/Area Number 19H02885
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 38030:Applied biochemistry-related
Research InstitutionKyoto Institute of Technology

Principal Investigator

TAKAO KATAOKA  京都工芸繊維大学, 応用生物学系, 教授 (20242307)

Co-Investigator(Kenkyū-buntansha) 木村 賢一  岩手大学, 農学部, 教授 (30344625)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywords炎症性サイトカイン / 低酸素応答 / バイオプローブ / TNF-α / NF-κB / HIF-1α / IFN-γ / ICAM-1
Outline of Final Research Achievements

In this study, the mechanisms by which ostruthin derivatives, isopanduratin A, α-conidendrin, and cucurbitacin B inhibited the tumor necrosis factor-α-induced nuclear factor κB signaling pathway were elucidated. The biological activities of ursane-type pentacyclic triterpenoids (including β-boswellic acid) on the expression and glycosylation of intercellular adhesion moleucule-1 and the biological activities of kujigamberol derivatives on interferon-γ expression were evaluated. Allantopyrone A was shown to stabilize hypoxia-inducible factor 1α by decreasing proteasome activity.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

本研究では、炎症性サイトカインによるシグナル伝達や遺伝子発現を制御する小分子化合物、及び低酸素応答のシグナル伝達を制御する小分子化合物の作用メカニズムを明らかにした点、並びにバイオプローブによる制御の可能性を示した点に学術的意義がある。さらに、炎症反応や低酸素応答における小分子化合物の作用メカニズムは、炎症性疾患や虚血性疾患等に対する予防薬や治療薬のリード化合物の創製への貢献が期待される点に社会的意義がある。

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Published: 2023-01-30  

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