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2022 Fiscal Year Final Research Report

Staging-based regenerative therapy for spinal cord injury in dogs

Research Project

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Project/Area Number 19H03123
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 42020:Veterinary medical science-related
Research InstitutionThe University of Tokyo

Principal Investigator

Ryohei Nishimura  東京大学, 大学院農学生命科学研究科(農学部), 教授 (80172708)

Co-Investigator(Kenkyū-buntansha) 藤田 直己  東京大学, 大学院農学生命科学研究科(農学部), 助教 (10554488)
西田 英高  大阪公立大学, 生命環境科学研究科, 研究員 (00622804)
伊藤 大介  日本大学, 生物資源科学部, 教授 (40508694)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywords犬 / 脊髄損傷 / 再生医療 / 間葉系幹細胞 / 骨髄脂肪細胞周囲細胞 / 急性期 / 亜急性期 / 慢性期
Outline of Final Research Achievements

We developed and applied regenerative medicine using bone marrow peri-adipocyte (BM-PAC) for spinal cord injury (SCI) in dogs. For acute SCI, we developed an intravenous administration of allogeneic BM-PAC. Allogeneic cells were immunized by the host, and sufficient therapeutic effects were not obtained, but safety was demonstrated with no serious complications. A clinical trial of self-administered intravenous BM-PAC was performed for subacute SCI. As a result of administering to one dog with spinal cord infarction, there were no serious complications, and recovery of walking function was obtained 3 months after administration. Thus, the safety and efficacy of intravenous administration of autologous BM-PACs were demonstrated. In addition, we clarified that neurospheres can be induced from BM-PAC. This result could contribute to the development and application of cell replacement therapy for chronic SCI.

Free Research Field

再生医療

Academic Significance and Societal Importance of the Research Achievements

小動物臨床において、犬の脊髄損傷疾患は再生医療の主要なターゲットであり、現在、自己あるいは他家間葉系幹細胞(MSC)の静脈投与が行われるようになってきたが、治療の有効性・安全性を示す科学的データが不足しており、問題となっている。本研究は、静脈投与されたMSCの体内分布や運動機能回復がどのようなメカニズムで得られる可能性があるかを示すものであり、それらの治療の有効性を支持する科学的データを供する。一方、他家MSC投与の有効性については否定的な結果であり、現在普及しつつある治療法に警鐘を鳴らすと同時に、どのような改善方法が考えられるかの道筋を示すものと考えられる。

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Published: 2024-01-30  

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