Study of signaling pathways for treatment of immune/allergic diseases

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03364
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
• Research Institution: Hokkaido University
• Principal Investigator: Matsuda Tadashi 北海道大学, 薬学研究院, 教授 (20212219)
• Co-Investigator(Kenkyū-buntansha): 室本 竜太 北海道大学, 薬学研究院, 准教授 (30455597) ; 柏倉 淳一 北海道大学, 薬学研究院, 講師 (90373290) ; 鍛代 悠一 北海道大学, 薬学研究院, 助教 (90756165)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: アレルギー / 免疫疾患 / 自己免疫 / サイトカイン / 免疫応答 / 炎症 / シグナル伝達

Outline of Final Research Achievements

Cytokines control the proliferation and differentiation as well as effecter functions of immune cells to eliminate invasive pathogens; however, they sometimes involve in the onset and development of immune/allergic diseases. We identified new regulatory molecules in the cytkine signaling and analyzed their functions. Among them, we focused on STAT3 / NF-κB-related signals, which are important for controlling the function of cytokines responsible for immune / allergic responses. However, the details of the involvement of these molecules in the development of immune / allergic diseases are not yet clear. In this study, we further examined functions of these STAT3 / NF-κB-related signaling molecules and showed new mechanisms in the onset of diseases such as allergies / immune diseases.This study will provide clues toward development of novel drugs for immune/allergic diseases in the near future.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

本研究で進めたSTAT3/NF-κB関連シグナルの研究は現在、蔓延するコロナ感染症での重症化にみられるサイトカインストームや間質性肺炎、ワクチン接種時にみられるアレルギー（即時型/遅延型）等の発症・進展の分子機序にも深く関与しており、新型コロナ重症化ならびにポストコロナにおける新たな疾患標的分子としての可能性も秘めており、本研究で焦点を当てたTyk2やSTAP-2の研究はその一助を担うものである。