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2021 Fiscal Year Final Research Report

Mechanism of nutritional programming in neurons

Research Project

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Project/Area Number 19H03367
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Research InstitutionInstitute of Physical and Chemical Research (2021)
The University of Tokyo (2019-2020)

Principal Investigator

Obata Fumiaki  国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (40748539)

Project Period (FY) 2019-04-01 – 2022-03-31
Keywords栄養応答 / アミノ酸 / チロシン / ショウジョウバエ / タンパク質制限 / DOHaD
Outline of Final Research Achievements

From this study, no significant changes in dopamine-related phenotypes, such as increased dopamine levels or enhanced memory learning ability, were observed in adults, which developed with tyrosine deficiency. Therefore, the involvement of dopamine in the irreversible physiological changes by tyrosine restriction was found to be limited. On the other hand, in the developing animals, restriction of the non-essential amino acid tyrosine induces ATF4-mediated adaptive responses to protein restriction, such as decreased protein synthesis, suppression of mTORC1 signalling and increased food intake.

Free Research Field

ショウジョウバエ遺伝学、分子生理学

Academic Significance and Societal Importance of the Research Achievements

非必須アミノ酸はがんなどの増殖性の高い細胞種で特異的に要求性が高まることから、治療戦略としてその食餌制限の有効性が着目されている。一方で正常個体では体内で十分生合成できるとされ、成長・生殖・摂食・寿命といった生理応答に対する重要性は必須アミノ酸と比べて乏しいと考えられてきた。タンパク質欠乏を感知し、環境適応するための鍵が一つの非必須アミノ酸であるという本研究の発見は、栄養応答研究分野に重要な知見をもたらすものと期待する。

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Published: 2023-01-30  

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