2021 Fiscal Year Final Research Report
Paratransgenesis of disease vector mosquito by fungi, bacteria, and cellular symbiont
Project/Area Number |
19H03462
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 49040:Parasitology-related
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Research Institution | Jikei University School of Medicine |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
大手 学 東京慈恵会医科大学, 医学部, 講師 (20386717)
相内 大吾 帯広畜産大学, 畜産学部, 助教 (50552783)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 蚊 / 病原体 / 感染症 / パラトランスジェネシス / 細菌 / 真菌 / ウイルス |
Outline of Final Research Achievements |
Mosquitoes transmit pathogens such as viruses and protozoa to humans through blood-sucking, causing infectious diseases such as dengue fever and malaria. In paratransgenesis, in which insect properties are indirectly modified by microbial intervention, we have identified the detailed mechanisms by which other species of microorganisms, such as insect viruses, fungi, and bacteria that infect mosquitoes, can affect the balance of interactions between mosquitoes and pathogens (induction of viral immune responses, the spread of bacteria within mosquito populations, and identification of fungal pathogenicity factors).
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Free Research Field |
衛生動物学
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Academic Significance and Societal Importance of the Research Achievements |
得られた研究成果から、宿主・病原体・媒介者の自然界でのライフサイクルの中で、媒介蚊が病原体と究極のバランスを取るための仕組み等が明らかになり、蚊に共存して介在する他者微生物もひとつの生命システムと捉える知見を提供した。それらの微生物の存在を利用し、そのバランスを敢えて崩すパラトランスジェネシスにより、蚊媒介性感染症制御に向けた新たな研究基盤とする独創性は高く、大きな波及効果が期待される。
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