Analysis of infection-induced hematopoiesis to develop therapy for infection and inflammation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03486
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Kanayama Masashi 東京医科歯科大学, 難治疾患研究所, 助教 (80811223)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 造血 / 感染 / 炎症 / 自然免疫

Outline of Final Research Achievements

Hematopoiesis is important for maintenance of homeostasis through supplying blood cells. Although hematopoiesis at steady state has been well understood, hematopoiesis induced by infection and inflammation has not been fully elucidated.　In this study, we found that conventional method to identify hematopoietic progenitor cells does not work to analyze hematopoiesis upon biological stresses and newly generated a method which allows identification of hematopoietic progenitors even under infection and inflammation. By using this novel method, we identified hematopoietic responses against infection/inflammation which cannot be identified by using the conventional method.

Free Research Field

免疫学、血液学

Academic Significance and Societal Importance of the Research Achievements

本研究では、これまで広く使用されてきた従来の造血前駆細胞同定法が、ストレス造血応答の解析には使用できないことを指摘するとともに、感染や炎症においても使用可能な新たな造血前駆細胞同定法を独自に樹立し、その有用性を証明した。この成果は、今後新たなストレス造血応答機構を発見するために非常に有用であるのに加え、過去のストレス造血応答に関連する研究報告を再検証する機会を与えるという意味において、免疫学や血液学に大きな影響を及ぼすと考えられる。