2022 Fiscal Year Final Research Report
Novel suppression of gastric carcinogenesis based on the spatiotemporal elucidation of H. pylori genome alterations identified using clinical samples
| Project/Area Number |
19H03521
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
|
|---|
| Research Institution | St. Marianna University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
伊東 文生 聖マリアンナ医科大学, 医学部, 教授 (90223180)
松尾 康正 聖マリアンナ医科大学, 医学部, 講師 (70724756)
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Keywords | H. pylori / ゲノム解析 / ゲノム多様性 / 胃洗浄廃液 / 胃癌 |
|---|
| Outline of Final Research Achievements |
Helicobacter pylori is a primary factor in the pathogenesis of gastric cancer. A clear understanding of the H. pylori genome factors underlying gastric cancer remains elusive. Based on long read next-generation sequencing of gastric wash and other samples, we identified gastric cancer-specific important alterations in the H. pylori genome. We revealed that these alterations can be used as novel molecular markers for gastric cancer. We also successfully characterized the functional significance of these alterations in gastric carcinogeneis. These results may help introduce early diagnostic and/or preventive measures for gastric cancer in patients infected with high-risk H. pylori strains. Thus, our findings can be applied to novel suppression of gastric carcinogenesis based on the spatiotemporal elucidation of H. pylori genome alterations identified using clinical samples.
|
| Free Research Field |
分子腫瘍学
|
| Academic Significance and Societal Importance of the Research Achievements |
ピロリ菌およびヒトゲノムの解析に基づく胃癌の本質的な基礎医学的分子病態の解明という点で、学術的意義が大きい。また、診断から除菌治療までの迅速遺伝子判定システムなどの臨床応用開発につながる成果であることから、社会的意義も大きい。
|
