2023 Fiscal Year Final Research Report
Development of a quantification method of seizure susceptibility using brain-wide electrical spatiotemporal dynamics
| Project/Area Number |
19H03550
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | Hokkaido University (2021-2023)
Osaka City University (2020)
Nagoya City University (2019) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大澤 匡弘 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 (80369173)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | てんかん / 脳波 / 発作感受性 / バイオマーカー / クロススペクトル因子分析法 / 脳深部刺激 / 非侵襲的脳刺激 |
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| Outline of Final Research Achievements |
In order to cure epilepsy, it is necessary to quantitatively and efficiently evaluate seizure susceptibility in the brain for the development of novel methods to reduce or eliminate seizure susceptibility. Therefore, the purpose of this study was to establish a technique for quantifying seizure susceptibility in epilepsy and a technique for controlling epileptic seizures through time-specific brain activity intervention, and to create a technological basis for methods to reduce or eliminate seizure susceptibility. First, we succeeded in quantifying seizure susceptibility by analyzing multi-brain region brain activity in disease model animals using cross-spectral factor analysis, a type of artificial intelligence technology. Furthermore, we achieved control of epileptic seizures by a time-targeted brain activity intervention method. In the future, the combination of such technologies can create methods to reduce or eliminate susceptibility to epileptic seizures.
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| Free Research Field |
神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
現在のてんかんの薬物療法は基本的に生涯続く対症療法であり就学就労妊娠制限で社会的損失を生じるため、根治療法を開発する必要がある。そのためには、一度脳内に形成された発作感受性を低減・消去する方法を見いだす必要があるが、発作感受性の定量法の欠如がてんかん根治療法の研究開発を妨げてきた。本研究により確立された、人工知能技術を利用した多脳領域脳活動データの解析によるてんかん発作感受性の定量法は、今後のてんかんの根治療法の研究開発における基盤的技術となる可能性がある。
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