Exploratory research to find the healthy aging factor in Kyotango area and Multifactorial AI Analysis collaborating with Hisayama Study andthe Iwaki Health Promotion Project

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H03567
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Matoba Satoaki 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10305576)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: aging / senescense / atherosclerosis / endotheial function / hearthy aging

Outline of Final Research Achievements

In the Kyotango area, the number of centenarians is about 2.7 times of the national average. In this study, we collected and accumulated health and medical data on about 2,000 factors from residents of Kyotango aged 65 and over.
As of March 2023, 950 health checkup data are analyzed, and AI analysis is currently being used to write a paper. We have published papers on aging, arteriosclerosis, and inflammation. We discovered that one amino acid in the blood is involved in maintenance of lifespan and exercise capacity, applied for a patent, and is currently continuing detailed analysis.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

京丹後地域と京都市の腸内細菌検査での比較研究では、京丹後地域においてプロテオバクテリア門が少なくいこと、大腸がんの罹患率が低い事を報告しているが、（J Clin Biochem Nutr. 2019 Sep;65(2):125-131.）。他にも多くの長寿に関係する因子を解析することで、今後人類が直面する高齢化社会において健康を維持する方法をみつけることができる。また、同じ健診項目で検討している青森県岩木町と京丹後地域の研究結果比較から両地域の行動パターンや、検査値の相違を検討し、健康長寿の医学的メカニズムを解明し、疾病の予防及び健康の保持・増進を広く社会に普及させることができる。