Machine learning using neuroimaging dataset around the onset of schizophrenia and the proposal for the optimal MRI protocol: An Asian multicenter study

2021 Fiscal Year Annual Research Report

• Project/Area Number: 19H03579
• Research Institution: The University of Tokyo
• Principal Investigator: 小池 進介 東京大学, 大学院総合文化研究科, 准教授 (10633167)
• Co-Investigator(Kenkyū-buntansha): 笹林 大樹 富山大学, 学術研究部医学系, 助教 (80801414) ; 平野 羊嗣 九州大学, 大学病院, 講師 (90567497)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 初発統合失調症 / 統合失調症ハイリスク群 / アジア精神病ＭＲＩ研究コンソーシアム / マルチモダリティ / 機械学習

Outline of Annual Research Achievements

小池は、ACMPは新型コロナウイルス感染症による制限が強いアジア諸国との共同研究であるため遅延しているが、ようやく参画7施設の脳構造データと臨床データを取りまとめ、現在前処理を一括して行っている。令和4年度に配布を開始する予定である。また、オンラインでシンポジウム発表などは積極的に行っている。笹林は、各ACMP参画施設と連携しつつ、採択された研究計画に必要な臨床・MRIデータの整理を行った。また、既存の国内多施設ECSデータを用いて合計7編の論文を作成した。平野は、国内外の脳波関連の共同研究施設と連携しつつ、臨床脳波を用いた国内の共同研究（7施設）に関する統括およひデータ収集、解析パイプラインの構築を完成させた。特に臨床脳波国内共同研究では、大規模データを用いて（治療抵抗性を含む）統合失調症における神経同期活動異常を見出し、その再現性も確認した。また、本研究に関わる論文15本を国際専門誌に投稿し受理された。

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] Seoul National University Hospital/Chonbuk National University Hospital/CHA Bundang Medical Center(韓国)
  • Country Name: KOREA (REP. OF KOREA)
  • Counterpart Institution: Seoul National University Hospital/Chonbuk National University Hospital/CHA Bundang Medical Center
  • # of Other Institutions: 2
• [Int'l Joint Research] Peking University Sixth Hospital/Shanghai Key Laboratory(中国)
  • Country Name: CHINA
  • Counterpart Institution: Peking University Sixth Hospital/Shanghai Key Laboratory
• [Int'l Joint Research] National Taiwan Univerisity Hospital/National Cheng Kung University Hospital(その他の国・地域)
  • Country Name: その他の国・地域
  • Counterpart Institution: National Taiwan Univerisity Hospital/National Cheng Kung University Hospital
• [Journal Article] Transdiagnostic Comparisons of Intellectual Abilities and Work Outcome in Patients with Mental Disorders: A Multicentre Study (2022)
  • Author(s): Sumiyoshi C, Ohi K, Fujino H, Yamamori H, Fujimoto M, Yasuda Y, UnobY, Takahashi J, Morita K, Katsuki A, Yamamoto M, Okahisa Y, Sata A, Katsumoto E, Koeda M, Hirano Y, Nakataki M, Matsumoto J, Miura K, Hashimoto N, Makinoda M, Takahashi T, Nemoto K, Kishimoto T, Suzuki M, Sumiyoshi T, Hashimoto R
  • Journal Title: BJPsych Open Volume: in press Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] DopaminergicDysfunction and Excitatory/Inhibitory Imbalance in Treatment-ResistantSchizophrenia and Novel Neuromodulatory Treatment. (2022)
  • Author(s): Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, Koike S,SasabayashiD, Katayama H, Plitman E, Ohi K, Ueno F, Caravaggio F,Koizumi T, Gerretsen P, Suzuki T, Uchida H, Mler DJ, Mimura M,Remington G, Grace AA, Graff-Guerrero A,Nakajima S.
  • Journal Title: Molecular Psychiatry Volume: in press Pages: -
  • Peer Reviewed / Open Access
• [Journal Article] Multi-modal imaging of the auditory-larynx motor network for voicing perception (2022)
  • Author(s): Shunsuke Tamura, Nobuyuki Hirose, Takako Mitsudo, Nobuhiko Hoaki, Itta Nakamura, Toshiaki Onitsuka, Yoji Hirano
  • Journal Title: NeuroImage Volume: 251 Pages: 118981-118981
  • DOI: 10.1016/j.neuroimage.2022
  • Peer Reviewed / Open Access
• [Journal Article] Shared functional impairment in the prefrontal cortex affects symptom severity across psychiatric disorders (2022)
  • Author(s): Koike S, Sakakibara E, Satomura Y, Sakurada H, Yamagishi M, Matsuoka J, Okada N, Kasai K
  • Journal Title: Psychol Med Volume: in press Pages: -
  • DOI: 10.1017/S0033291720004742
  • Peer Reviewed
• [Journal Article] Dopaminergic dysfunction and excitatory/inhibitory imbalance in treatment-resistant schizophrenia and novel neuromodulatory treatment (2022)
  • Author(s): Wada M, Noda Y, Iwata Y, Tsugawa S, Yoshida K, Tani H, Hirano Y, Koike S, Sasabayashi D, Katayama H, Plitman E, Ohi K, Ueno F, Caravaggio F, Koizumi T, Gerretsen P, Suzuki T, Uchida H, Muller DJ, Mimura M, Remington G, Grace AA, Graff-Guerrero A, Nakajima S
  • Journal Title: Molecular Psychiatry Volume: in press Pages: -
  • DOI: 10.1038/s41380-022-01572-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nutrient infusion evoked magnetic resonance imaging signal in the human hypothalamus (2022)
  • Author(s): Nakamura Y, Takahashi M, Inoue Y, Yanagimoto S, Okanoya K, Koike S
  • Journal Title: Nutr Neurosci Volume: in press Pages: -
  • DOI: 10.1080/1028415X.2021.1983102
  • Peer Reviewed
• [Journal Article] Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial (2022)
  • Author(s): Yamasue H, Kojima M, Kuwabara H, (34名), Hirano Y, Onitsuka T, Kosaka H, Okada T
  • Journal Title: Brain Volume: 145 Pages: 490-499
  • DOI: 10.1093/brain/awab291
  • Peer Reviewed / Open Access
• [Journal Article] Volume reduction of the dorsal lateral prefrontal cortex prior to the onset of frank psychosis in individuals with an at-risk mental state. (2022)
  • Author(s): Takayanagi Y, Kulason S, Sasabayashi D, Takahashi T, Katagiri N, Sakuma A, Ohmuro N, Katsura M, Nakamura M, Kido M, Furuichi A, Nishikawa Y, Noguchi K, Matsumoto K, Mizuno M, Ratnanather JT, Suzuki M
  • Journal Title: Cerebral Cortex Volume: in press Pages: -
  • DOI: 10.1093/cercor/bhab353
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Application of a machine learning algorithm for structural brain images in chronic schizophrenia to earlier clinical stages of psychosis and autism spectrum disorder: A multi-protocol imaging dataset study (2022)
  • Author(s): Zhu Y, Nakatani H, Yassin W, Maikusa N, Okada N, Kunimatsu A, Abe O, Kuwabara H, Yamasue H, Kasai K, Okanoya K, Koike S
  • Journal Title: Schizophr Bull Volume: in press Pages: -
  • DOI: 10.1093/schbul/sbac030
  • Peer Reviewed / Open Access
• [Journal Article] Trends in Big Data Analyses by Multicenter Collaborative Translational Research in Psychiatry (2022)
  • Author(s): Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 76 Pages: 14-Jan
  • DOI: 10.1111/pcn.13311
  • Peer Reviewed / Open Access
• [Journal Article] Toward Recovery in Schizophrenia: Current Concepts, Findings, and Future Research Directions (2022)
  • Author(s): Toshiaki Onitsuka, Yoji Hirano, Takanobu Nakazawa, Kayo Ichihashi, Kenichiro Miura, Ken Inada, Ryo Mitoma, Norio Yasui_Furukori, Ryota Hashimoto
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: in press Pages: -
  • DOI: 10.1111/pcn.13342
  • Peer Reviewed / Open Access
• [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools (2022)
  • Author(s): Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: in press Pages: -
  • DOI: 10.2463/mrms.rev.2021-0050
  • Peer Reviewed / Open Access
• [Journal Article] Structural MRI measures associated with psychosis onset in individuals at clinical high risk for developing psychosis: An ENIGMA Working Group mega-analysis (2021)
  • Author(s): ENIGMA Clinical High Risk for Psychosis Working Group; Jalbrzikowski M, Hayes RA, Wood SJ, (19名), Koike S, (71名), Sasabayashi D, (22名), Thompson PM, Hernaus D
  • Journal Title: JAMA Psychiatry Volume: 78 Pages: 753-66
  • DOI: 10.1001/jamapsychiatry.2021.0638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of travelling-subject and ComBat harmonization methods for assessing structural brain characteristics (2021)
  • Author(s): Maikusa N, Zhu Y, Uematsu A, Yamashita A, Saotome K, Okada N, Kasai K, Okanoya K, Yamashita O, Tanaka SC, Koike S
  • Journal Title: Hum Brain Mapp Volume: 42 Pages: 5278-87
  • DOI: 10.1002/hbm.25615
  • Peer Reviewed / Open Access
• [Journal Article] Effects of age and sex on eye movement characteristics (2021)
  • Author(s): Junichi Takahashi, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Seiko Miyata, Kosuke Okazaki, Junya Matsumoto, Naomi Hasegawa, Yoji Hirano, Hidenaga Yamamori, Yuka Yasuda, Manabu Makinodan, Kiyoto Kasai, Norio Ozaki, Toshiaki Onitsuka, Ryota Hashimoto
  • Journal Title: Neuropsychopharmacology Reports Volume: 41 Pages: 152-158
  • DOI: 10.1002/npr2.12163
  • Peer Reviewed / Open Access
• [Journal Article] Unique morphometric features of the cerebellum and cerebellocerebral structural correlation between autism spectrum disorder and schizophrenia (2021)
  • Author(s): Morimoto C, Nakamura Y, Kuwabara H, Abe O, Kasai K, Yamasue H, Koike S
  • Journal Title: Biol Psychiatry: Global Open Science Volume: 1 Pages: 219-28
  • DOI: 10.1016/j.bpsgos.2021.05.010
  • Peer Reviewed / Open Access
• [Journal Article] Intergenerational transmission of the patterns of functional and structural brain networks (2021)
  • Author(s): Takagi Y, Okada N, Ando S, Yahata N, Morita K, Koshiyama D, Kawakami S, Sawada K, Koike S, Endo K, Yamasaki S, Nishida A, Kasai K, Tanaka SC
  • Journal Title: iScience Volume: 24 Pages: 102708
  • DOI: 10.1016/j.isci.2021.102708
  • Peer Reviewed / Open Access
• [Journal Article] Oscillatory brain network changes after transcranial magnetic stimulation treatment in patients with major depressive disorder (2021)
  • Author(s): Ryo Mitoma, Shunsuke Tamura, Hiroshi Tateishi, Takako Mitsudo, Ichiro Tanabe, Akira Monji, Yoji Hirano*
  • Journal Title: Journal of Affective Disorders Reports Volume: 7 Pages: 100277-100277
  • DOI: 10.1016/j.jadr.2021.100277
  • Peer Reviewed / Open Access
• [Journal Article] Cross-scanner reproducibility and harmonization of a diffusion MRI structural brain network: A traveling subject study of multi-b acquisition (2021)
  • Author(s): Kurokawa R, Kamiya K, Koike S, Nakaya M, Uematsu A, Tanaka SC, Kamagata K, Okada N, Morita K, Kasai K, Abe O
  • Journal Title: NeuroImage Volume: 245 Pages: 118675
  • DOI: 10.1016/j.neuroimage.2021.118675
  • Peer Reviewed / Open Access
• [Journal Article] Brain/MINDS?Beyond?Human?Brain?MRI?Project:?A?protocol?for?multi-level?harmonization?across?brain?disorders?throughout?the?lifespan (2021)
  • Author(s): Koike S, Tanaka SC, Okada T, (25名), Hayashi T, Brain/MINDS Beyond Human Brain MRI Group
  • Journal Title: NeuroImage Clin Volume: 30 Pages: 102600
  • DOI: 10.1016/j.nicl.2021.102600
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Potential contribution of pineal atropy and pineal cysts toward vulnerability and clinical characteristics of psychosis. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Akasaki Y, Nishiyama S, Furuichi A, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: NeuroImage: Clinical Volume: 32 Pages: 102805
  • DOI: 10.1016/j.nicl.2021.102805
  • Peer Reviewed / Open Access
• [Journal Article] Altered Heschl’s gyrus duplication pattern in first-episode schizophrenia. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Schizophrenia Research Volume: 237 Pages: 174-181
  • DOI: 10.1016/j.schres.2021.09.011
  • Peer Reviewed
• [Journal Article] Anomalous brain gyrification patterns in major psychiatric disorders: A systematic review and transdiagnostic integration. (2021)
  • Author(s): Sasabayashi D, Takahashi T, Takayanagi Y, Suzuki M
  • Journal Title: Translational Psychiatry Volume: 11 Pages: 176
  • DOI: 10.1038/s41398-021-01297-8
  • Peer Reviewed / Open Access
• [Journal Article] Reduced cortical thickness of the paracentral lobule in at-risk mental state individuals with poor one-year functional outcomes (2021)
  • Author(s): Sasabayashi D, Takayanagi Y, Takahashi T, Nishiyama S, Mizukami Y, Katagiri N, Tsujino N, Nemoto T, Sakuma A, Katsura M, Ohmuro N, Okada N, Tada M, Suga M, Maikusa N, Koike S, Furuichi A, Kido M, Noguchi K, Yamasue H, Matsumoto K, Mizuno M, Kasai K, Suzuki M
  • Journal Title: Translational Psychiatry Volume: 11 Pages: 396
  • DOI: 10.1038/s41398-021-01516-2
  • Peer Reviewed / Open Access
• [Journal Article] Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis (2021)
  • Author(s): Koike S, Fujioka M, Satomura Y, Koshiyama D, Tada M, Sakakibara E, Okada N, Takano Y, Iwashiro N, Natsubori T, Zhu Y, Abe O, Kirihara K, Yamasue H, Kasai K
  • Journal Title: npj Schizophr Volume: 7 Pages: 56
  • DOI: 10.1038/s41537-021-00186-9
  • Peer Reviewed / Open Access
• [Journal Article] Birth order and prosociality in the early adolescent brain (2021)
  • Author(s): Okada N, Yamamoto Y, Yahata N, Morita S, Koshiyama D, Morita K, Sawada K, Kanata S, Fujikawa S, Sugimoto N, Toriyama R, Masaoka M, Koike S, Araki T, Kano Y, Endo K, Yamasaki S, Ando S, Nishida A, Hiraiwa-Hasegawa M, Yokoyama C, Kasai K
  • Journal Title: Sci Rep Volume: 11 Pages: 21806
  • DOI: 10.1038/s41598-021-01146-0
  • Peer Reviewed / Open Access
• [Journal Article] Features of duration mismatch negativity around the onset of overt psychotic disorders: A longitudinal study. (2021)
  • Author(s): Tateno T, Higuchi Y, Nakajima S, Sasabayashi D, Nakamura M, Ueno M, Mizukami Y, Nishiyama S, Takahashi T, Sumiyoshi T, Suzuki M
  • Journal Title: Cerebral Cortex Volume: 31 Pages: 2416~2424
  • DOI: 10.1093/cercor/bhaa364
  • Peer Reviewed
• [Journal Article] Dietary restraint related to body weight maintenance and neural processing in value-coding areas in adolescents (2021)
  • Author(s): Nakamura Y, Ando S, Yamasaki S, Okada N, Nishida A, Kasai K, Tanaka S, Nakatani H, Koike S
  • Journal Title: J Nutr Volume: 151 Pages: 2059-67
  • DOI: 10.1093/jn/nxab068
  • Peer Reviewed
• [Journal Article] Neurocognitive deficits mediate the relationship between structural abnormalities and clinical outcomes in individuals with ultra-high risk for psychosis: A multi-modal neuroimaging and longitudinal neurocognitive study (2021)
  • Author(s): Koike S, Fujioka M, Takano Y, Iwashiro N, Satomura Y, Nagai T, Koshiyama D, Tada M, Natsubori T, Okada N, Abe O, Kirihara K, Yamasue H, Suga M, Kasai K
  • Journal Title: Schizophr Bull Open Volume: 2 Pages: sgab027
  • DOI: 10.1093/schizbullopen/sgab027
  • Peer Reviewed / Open Access
• [Journal Article] Recent Findings on Neurofeedback Training for Auditory Hallucinations in Schizophrenia (2021)
  • Author(s): Yoji Hirano*, Shunsuke Tamura
  • Journal Title: Current Opinion in Psychiatry Volume: 34 Pages: 245-252
  • DOI: 10.1097/yco.000000000000
  • Peer Reviewed / Open Access
• [Journal Article] Recent updates of eye movement abnormalities in patients with schizophrenia: A scoping review (2021)
  • Author(s): Alexandra Wolf, Kazuo Ueda, Yoji Hirano*
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Pages: 82-100
  • DOI: 10.1111/pcn.13188
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Volumetric differences in gray and white matter of cerebellar Crus I/II across the different clinical stages of schizophrenia (2021)
  • Author(s): Morimoto C, Uematsu A, Nakatani H, Takano Y, Iwashiro N, Abe O, Yamasue H, Kasai K, Koike S
  • Journal Title: Psychiatry Clin Neurosci Volume: 75 Pages: 256-64
  • DOI: 10.1111/pcn.13277
  • Peer Reviewed
• [Journal Article] Current Findings and Perspectives on Aberrant Neural Oscillations in Schizophrenia (2021)
  • Author(s): Yoji Hirano*, Peter J. Uhlhaas
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 75 Pages: 358-368
  • DOI: 10.1111/pcn.13300
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] AKR1A1 variant associated with schizophrenia causes exon skipping, leading to loss of enzymatic activity (2021)
  • Author(s): Iino K, Toriumi K, Agarie R, Miyashita M, Suzuki K, Horiuchi Y, Niizato K, Oshima K, Imai A, Nagase Y, Kushima I, Koike S, Ikegame T, Jinde S, Nagata E, Washizuka S, Miyata T, Takizawa S, Hashimoto R, Kasai K, Ozaki N, Itokawa M, Arai M
  • Journal Title: Front Genet Volume: 12 Pages: 762999
  • DOI: 10.3389/fgene.2021.762999
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal changes in brain gyrification in schizophrenia spectrum disorders. (2021)
  • Author(s): Pham TV, Sasabayashi D, Takahashi T, Takayanagi Y, Kubota M, Furuichi A, Kido M, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Aging Neuroscience Volume: 13 Pages: 752575
  • DOI: 10.3389/fnagi.2021.752575
  • Peer Reviewed / Open Access
• [Journal Article] Heschl’s gyrus duplication pattern in individuals at risk of developing psychosis and patients with schizophrenia. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Higuchi Y, Mizukami Y, Nishiyama S, Furuichi A, Kido M, Pham TV, Kobayashi H, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 15 Pages: 647069
  • DOI: 10.3389/fnbeh.2021.647069
  • Peer Reviewed / Open Access
• [Journal Article] Association of disinhibited eating and trait of impulsivity with insula and amygdala responses to palatable liquid consumption (2021)
  • Author(s): Nakamura Y, Koike S
  • Journal Title: Front System Neurosci Volume: 15 Pages: 647143
  • DOI: 10.3389/fnsys.2021.647143
  • Peer Reviewed / Open Access
• [Journal Article] Development of metacognition in adolescence: The congruency-based metacognition scale (2021)
  • Author(s): Kawata KH, Ueno Y, Hashimoto R, Yoshino S, Ohta K, Nishida A, Ando S, Nakatani H, Kasai K, Koike S
  • Journal Title: Front Psychol Volume: 11 Pages: 565231
  • DOI: 10.3389/fpsyg.2020.565231
  • Peer Reviewed / Open Access
• [Journal Article] Reduced hippocampal subfield volume in schizophrenia and clinical high-risk state for psychosis. (2021)
  • Author(s): Sasabayashi D, Yoshimura R, Takahashi T, Takayanagi Y, Nishiyama S, Higuchi Y, Mizukami Y, Furuichi A, Kido M, Nakamura M, Noguchi K, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 642048
  • DOI: 10.3389/fpsyt.2021.642048
  • Peer Reviewed / Open Access
• [Journal Article] Current MEG Research in Psychiatry (2021)
  • Author(s): Yoji Hirano*, Peter J. Uhlhaas
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 647085
  • DOI: 10.3389/fpsyt.2021.647085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Abnormality of resting-state functional connectivity in major depressive disorder: A study with whole-head near-infrared spectroscopy (2021)
  • Author(s): Sakakibara E, Satomura Y, Matsuoka J, Koike S, Okada N, Sakurada H, Yamagishi M, Kawakami N, Kasai K
  • Journal Title: Front Psychiatry Volume: 12 Pages: 664859
  • DOI: 10.3389/fpsyt.2021.664859
  • Peer Reviewed / Open Access
• [Journal Article] Eye Movement Abnormalities in Major Depressive Disorder (2021)
  • Author(s): Junichi Takahashi, Yoji Hirano*, Kenichiro Miura, Kentaro Morita, Michiko Fujimoto, Hidenaga Yamamori, Yuka Yasuda, Noriko Kudo, Emiko Shishido, Kosuke Okazaki, Tomoko Shiino, Tomohiro Nakao, Kiyoto Kasai, Ryota Hashimoto, Toshiaki Onitsuka
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 673443
  • DOI: 10.3389/fpsyt.2021.673443
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal bidirectional relationships between maternal depressive/anxious symptoms and children’s tic frequency in early adolescence (2021)
  • Author(s): Yagi T, Ando S, Usami S, Yamasaki S, Morita M, Kiyono T, Hayashi N, Endo K, Iijima Y, Morimoto Y, Kanata S, Fujikawa S, Koike S, Kano Y, Hiraiwa-Hasegawa M, Nishida A, Kasai K
  • Journal Title: Front Psychiatry Volume: 16 Pages: 767571
  • DOI: 10.3389/fpsyt.2021.767571
  • Peer Reviewed / Open Access
• [Journal Article] Duration mismatch negativity predicts remission in first-episode schizophrenia patients. (2021)
  • Author(s): Nakajima S, Higuchi Y, Tateno T, Sasabayashi D, Mizukami Y, Nishiyama S, Takahashi T, Suzuki M
  • Journal Title: Frontiers in Psychiatry Volume: 12 Pages: 777378
  • DOI: 10.3389/fpsyt.2021.777378
  • Peer Reviewed / Open Access
• [Journal Article] Increased Heschl’s gyrus duplication in schizophrenia spectrum disorders: A cross-sectional MRI study. (2021)
  • Author(s): Takahashi T, Sasabayashi D, Takayanagi Y, Furuichi A, Kido M, Pham TV, Kobayashi H, Noguchi K, Suzuki M.
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 40
  • DOI: 10.3390/jpm11010040
  • Peer Reviewed / Open Access
• [Journal Article] Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study (2021)
  • Author(s): Jinya Sato, Yoji Hirano*, Noriaki Hirakawa, Junichi Takahashi, Naoya Oribe, Hironori Kuga, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao, Toshiaki Onitsuka
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 121-121
  • DOI: 10.3390/jpm11020121
  • Peer Reviewed / Open Access
• [Journal Article] Prolonged P300 Latency in Antipsychotic-Free Subjects with At-Risk Mental States Who Later Developed Schizophrenia. (2021)
  • Author(s): Higuchi Y, Sumiyoshi T, Tateno T, Nakajima S, Sasabayashi D, Nishiyama S, Mizukami Y, Takahashi T, Suzuki M
  • Journal Title: Journal of Personalized Medicine Volume: 11 Pages: 327
  • DOI: 10.3390/jpm11050327
  • Peer Reviewed / Open Access
• [Presentation] 精神病発症危険状態における脳幹体積の検討. (2021)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 藤本岳, 片桐直之, 佐久間篤, 小原千佳, 桂雅宏, 岡田直大, 小池進介, 中村美保子, 古市厚志, 木戸幹雄, 西川祐美子, 野口京, 山末英典, 笠井清登, 松本和紀, 水野雅文, 鈴木道雄.
  • Organizer: 第15回日本統合失調症学会
• [Presentation] 精神病発症危険状態におけるgyrificationの偏倚と認知機能障害との関連. (2021)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 西山志満子, 水上祐子, 片桐直之, 辻野尚久,根本隆洋, 佐久間篤, 桂雅宏, 大室則幸, 岡田直大, 多田真理子, 管心, 小池進介, 山末英典,松本和紀, 水野雅文, 笠井清登, 鈴木道雄.
  • Organizer: 第15回日本統合失調症学会
• [Presentation] 統合失調症およびAt-risk mental stateにおける海馬の亜領域の体積変化. (2021)
  • Author(s): 吉村亮, 笹林大樹, 高橋努, 高柳陽一郎, 西山志満子, 樋口悠子, 水上祐子, 古市厚志, 木戸幹雄, 中村美保子, 野口京, 鈴木道雄.
  • Organizer: 第15回日本統合失調症学会
• [Presentation] 精神疾患における脳溝・脳回パターンの偏倚 -疾患横断的・疾患特異的な病態神経回路の解明に向けて-. (2021)
  • Author(s): 笹林大樹
  • Organizer: 第43回 日本生物学的精神医学会 第51回 日本神経精神薬理学会 合同年会
• [Presentation] 初回エピソード統合失調症患者における脳溝・脳回パターンの偏倚とその後の再燃との関連. (2021)
  • Author(s): 笹林大樹, 高柳陽一郎, 高橋努, 古市厚志, Tien Viet Pham, 小林春子, 野口京, 鈴木道雄.
  • Organizer: 第24回日本精神保健・予防学会学術集会
• [Presentation] 精神疾患における脳溝・脳回パターンの偏倚 -疾患横断的・疾患特異的なバイオマーカー開発に向けて-. (2021)
  • Author(s): 笹林大樹
  • Organizer: 第198回北陸精神神経学会
• [Presentation] 精神病ハイリスク群と初回エピソード精神病群におけるマルチモダリティ脳計測と臨床転帰の関係 (2021)
  • Author(s): 小池進介
  • Organizer: 第24回日本精神保健・予防学会学術集会
• [Presentation] The progress of the Asian Consortium on MRI studies in Psychosis (ACMP) (2021)
  • Author(s): Koike S, Morita K, Okada N, Xin Yu, Jun Soo Kwon, Kasai K
  • Organizer: 8th BESETO International Psychiatry Conference
  • Int'l Joint Research
• [Presentation] 1,000 計測以上の縦断脳画像データの解析技法開発と臨床応用 (2021)
  • Author(s): 小池進介
  • Organizer: 第43回 日本生物学的精神医学会 第51回 日本神経精神薬理学会 合同年会
• [Presentation] Machine learning-based prediction for different clinical stages of SZ spectrum: A multisite cross-disease volumetric MRI analysis (2021)
  • Author(s): Koike S
  • Organizer: The 15th World Congress of Biological Psychiatry
  • Int'l Joint Research
• [Presentation] ヒト神経科学の現在地:脳画像研究でわかる思春期発達 (2021)
  • Author(s): 小池進介
  • Organizer: 埼玉県公認心理師協会 令和3年度大会
• [Presentation] 青少年脳に関する神経科学の知見 (2021)
  • Author(s): 小池進介
  • Organizer: 第99回日本刑法学会
• [Presentation] 前頭前野機能と社会機能：疾患横断大規模近赤外線スペクトロスコピィ研究 (2021)
  • Author(s): 小池進介
  • Organizer: 第15回日本統合失調症学会
• [Remarks] Asian Consortium on MRI in Psychosis
  • URL: http://asia-mri-consortium.net/