2021 Fiscal Year Final Research Report
Basic research to achieve precision medicine for hepatocarcinoma occurring in the era of hepatitis virus eradication/suppression.
| Project/Area Number |
19H03638
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 肝炎ウイルス制御後 / 原発性肝癌 / HCV / 次世代シークエンサー / 自然免疫 / ウイルスゲノム / 宿主遺伝子 |
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| Outline of Final Research Achievements |
Progression of liver disease or the occurrence of hepatocellular carcinoma (HCC) is still observed in some virus hepatitis patients even after virus elimination with antiviral drugs, and the underlying mechanism is unclear. In this study, using next-generation gene analysis technology, we characterized the information and the dynamics of hepatitis C virus (HCV) genome, HCC genome, and inflammation-related molecules in HCV patients who experienced liver disease advancement or HCC development after viral elimination.
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| Free Research Field |
ウイルス性肝炎
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| Academic Significance and Societal Importance of the Research Achievements |
学術的には、本研究によってウイルス排除後の肝病態進展/発癌に関する肝癌ゲノムの特徴、炎症性サイトカインの動態と病態進展の関連、ハプロタイピングシステムを用いたウイルスゲノムの特徴と病態進展の関連を示すことができた。
また今回構築したhTERT C228T定量リキッドバイオプシーシステムは、正確かつ簡便な肝癌検出および治療反応性の予測が行えるため、直接臨床現場に導入しうる。
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