2022 Fiscal Year Final Research Report
Clarification of the roles of gut microbiome in cardiovascular diseases and search for novel therapeutic targets
Project/Area Number |
19H03653
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 53020:Cardiology-related
|
Research Institution | Kobe University |
Principal Investigator |
Yamashita Tomoya 神戸大学, 大学院科学技術イノベーション研究科, 教授 (90437468)
|
Project Period (FY) |
2019-04-01 – 2023-03-31
|
Keywords | 循環器疾患 / 腸内細菌 / 心不全 / 心房細動 / 大動脈瘤 / 炎症 |
Outline of Final Research Achievements |
We investigated gut bacteria in patients with heart failure, atrial fibrillation, and aortic aneurysm, and clarified disease-specific gut flora. In aortic aneurysm, we elucidated the role of gut microbiota by sterilizing them with antibiotics. Bacteroides, identified as anti-atherogenic bacteria, was shown to improve branched-chain amino acid metabolism and suppress obesity in obese mouse models. We investigated the aggravating action of LPS on atherosclerosis and its mechanism, and elucidated the mechanism of exacerbation of inflammation, including the formation of neutrophil extracellular traps (NETs) in atherosclerotic lesions and increased production of chemokines from macrophages. While investigating the relationship between gut microbiota and cardiovascular diseases, we were able to clarify the influence of bacteria on host's metabolism and immunity.
|
Free Research Field |
循環器内科学
|
Academic Significance and Societal Importance of the Research Achievements |
腸内細菌と各種循環器疾患との関連性を調査した研究であり、その関係性の中から、新規の治療標的や治療法を開発することを目指して研究を進めた。循環器疾患と腸内細菌との関連研究は、日本ではほぼ我々の研究が中心となっており、今回は4年間の継続した研究実施の中で、本当に数多くの臨床的エビデンスから、基礎研究での成果も得られた。今後の研究に活かし、発展させて患者貢献できると考えている。
|