2021 Fiscal Year Final Research Report
Epidermal stem cell dynamics during pregnancy
| Project/Area Number |
19H03681
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
Toyoshima Fumiko 京都大学, ウイルス・再生医科学研究所, 教授 (40397576)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 幹細胞 / 皮膚 / 妊娠 |
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| Outline of Final Research Achievements |
The skin surface area changes during life course. During pregnancy, the abdominal skin expands rapidly to accommodate the fetus grows, but its biological mechanism remains unknown.We previously reported that epidermal stem cells generate high proliferative basal cell progeny (Tbx3 + basal cells) that promotes skin expansion during pregnancy. In this study, we showed that Tbx3 + basal cells are vasculature-dependent epidermal stem cell population, which appear during pregnancy with a concomitant angiogenesis and undergo differentiation after parturition upon vasculature involution.In addition, when tension load was applied to the skin, skin vasculature increased even in non-pregnancy, and Tbx3 + basal cells were induced concomitantly, demonstrating that vasculatures and tension are important for skin extension. rice field.
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| Free Research Field |
生物学
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| Academic Significance and Societal Importance of the Research Achievements |
妊娠期の皮膚リモデリング機構において、皮膚拡張を担う表皮細胞増殖クラスターの形成機構を解明し、その分子基盤を示した。また、血管新生を阻害すると表皮細胞増殖クラスターの出現が抑制されることを示し、皮膚リモデリング機構における血管の重要性を明らかにした。さらに、張力負荷により血管新生と表皮増殖クラスターが誘導されることを見出し、妊娠と張力による皮膚リモデリングの共通性を明らかにした。皮膚の医療・美容領域においては、力刺激を用いたケアが広く普及している。本研究は、これらの力学セラピーに対する生物学的根拠を提示するものである。
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