Identification of the metabolic roles of SIRT7 and the development of its regulation.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03711
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Kumamoto University
• Principal Investigator: Yamagata Kazuya 熊本大学, 大学院生命科学研究部(医), 教授 (70324770)
• Co-Investigator(Kenkyū-buntansha): 吉澤 達也 熊本大学, 大学院生命科学研究部(医), 准教授 (40313530) ; 佐藤 叔史 熊本大学, 大学院生命科学研究部(医), 助教 (90622598)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: サーチュイン / SIRT7 / 脂肪細胞 / 炎症

Outline of Final Research Achievements

Sirtuins (SIRT1-SIRT7 in mammals) are NAD-dependent lysine deacetylase/deacylase that regulate diverse biological processes. However, the biological function of SIRT7 is largely unknown. In the present study, we identified that SIRT7 controls lipogenesis in adipocytes through the deacetylation of transcription factor PPARγ . We also identified that SIRT7 regulates the nuclear accumulation of NF-kB by deacetylating Ran, a small GTPase Ras related nuclear antigen. These results indicate that SIRT7 plays important roles in lipid metabolism and inflammation.

Free Research Field

代謝学

Academic Significance and Societal Importance of the Research Achievements

肥満や炎症反応を制御する新たな方法の開発は、現在社会における重要な医学的課題である。本研究の結果、SIRT7の阻害が肥満や炎症反応を減弱させることが判明した。SIRT7阻害剤の開発が、種々の疾患の治療法開発につながる可能性が示された。