2021 Fiscal Year Final Research Report

Elucidation of malignancy, peritoneal dissemination and spread mechanism of ovarian cancer by interaction with peritoneal mesothelium.

Research Project

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Project/Area Number	19H03797
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Nagoya University
Principal Investigator	Kikkawa Fumitaka 名古屋大学, 医学系研究科, 招へい教員 (40224985)
Co-Investigator(Kenkyū-buntansha)	梶山広明名古屋大学, 医学系研究科, 教授 (00345886) 横井暁名古屋大学, 医学部附属病院, 助教 (30737135) 芳川修久名古屋大学, 医学部附属病院, 助教 (60804747) 鈴木史朗愛知県がんセンター(研究所), 婦人科部, 部長 (20612758)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	卵巣癌 / がん微小環境 / 細胞間相互作用
Outline of Final Research Achievements	The aim of this study was to elucidate new disease mechanisms by focusing on cell-cell interactions in the ovarian cancer tumor-microenvironment (TME), and to discover novel therapeutic targets for ovarian cancer patients. Throughout the three-year research period, we have elucidated the malignant mechanisms of refractory ovarian cancer from extremely multiple aspects. The research included metabolomic analysis, small RNA sequencing, therapeutic effects of vitamins, and the relationship with adipose tissue. All of the results are the whole new findings, which have been reported for the first time. The function of mesothelial cells in TME is still under investigation. Although this research grant is in its final year, we will continue to elucidate the functions of various cells in the ovarian cancer TME and leading to develop them for clinical applications such as diagnosis and treatment.
Free Research Field	腫瘍生物学
Academic Significance and Societal Importance of the Research Achievements	卵巣がんは、婦人科悪性腫瘍の中で最も予後不良ながん種であり、罹患率・死亡率ともに上昇の一途を辿っている。卵巣がん細胞は極めて腹膜播種を起こしやすく、診断時多くの症例で腹膜播種を伴っており、重要な予後因子の一つとなっている。また、腹膜播種に対する有効な治療法は現在も確立されているとはいえず、腹膜播種巣での分子生理機構もほとんど明らかにされていない。本研究はこうした卵巣がんの課題に対して、解決の糸口となり得る知見と考えている。