Establishment of novel vascular regeneration therapy by investigation the newly found vascular macrophage

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03816
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Juntendo University
• Principal Investigator: Rica Tanaka 順天堂大学, 医学部, 教授 (70509827)
• Co-Investigator(Kenkyū-buntansha): 水野 博司 順天堂大学, 医学部, 教授 (80343606) ; 西貝 燕 順天堂大学, 医学部, 博士研究員 (80614007) ; 山口 茂夫 順天堂大学, 医学部, 非常勤助教 (40747797)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: マクロファージ / 糖尿病 / 細胞治療 / 創傷治癒 / 末梢血単核球

Outline of Final Research Achievements

The applicant has developed a technique for in vitro functional enhancement and cell amplification of M2 macrophages in peripheral blood of patients with intractable ulcers. Interestingly, we found characteristic macrophages in the cells obtained from the culture that were positively correlated with the therapeutic effect of vascular regeneration. In this study, the applicant's original discovery of the cytological properties and vascular regeneration mechanism of this cell was elucidated. The results obtained from this study will lead to develop a new therapeutic method that will bring about more effects than the current cell transplantation therapy for vascular regeneration.

Free Research Field

形成外科、再生医療、創傷外科、足病医学

Academic Significance and Societal Importance of the Research Achievements

本研究により高い血管再生機能を有する新たなマクロファージ細胞であるReMa細胞が実証され血管再生機構における新たな発展が見いだせた。今後は本細胞により現在の細胞移植治療以上の血管再生・組織再生効果をもたらす新規治療法の開発につながる。さらに本法は糖尿病虚血性潰瘍への治療だけでなく、他の臓器における慢性炎症環境を制御する可能性もあり、多くの慢性炎症・虚血に起因する疾患の理解と制御を通じて、医学の発展に大きく貢献できる。