2022 Fiscal Year Final Research Report

Causal inference in the association between oral health and general health using big data

Research Project

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Project/Area Number	19H03860
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 57080:Social dentistry-related
Research Institution	Tokyo Medical and Dental University (2020-2022) Tohoku University (2019)
Principal Investigator	Aida Jun 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80463777)
Co-Investigator(Kenkyū-buntansha)	花里真道千葉大学, 予防医学センター, 准教授 (00608656) 山本龍生神奈川歯科大学, 歯学部, 教授 (20252984) 近藤克則千葉大学, 予防医学センター, 教授 (20298558) 小坂健東北大学, 歯学研究科, 教授 (60300935)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	口腔と全身の健康 / 固定効果分析 / 媒介分析 / 集団寄与危険割合 / 認知症 / 死亡
Outline of Final Research Achievements	In recent years, there has been an increased focus on causal inference using observational data, as it has been recognized that randomized controlled trials (RCTs) sometimes cannot be conducted. In this study, we used a variety of techniques on observational data to examine the relationship between oral and systemic health. A study of denture cleaning frequency and pneumonia risk, a study of oral health and cognitive decline, studies of oral health and social activity and isolation, a study showing that oral functions such as speaking and eating exist as mechanisms by which poor oral health increases the risk of depression, a study showing the same with dementia, a study showing that oral health contributes more than other risks studies showing that oral health contributes more than other risks to mortality, a study of prosthetic treatment and weight loss, a study of oral function and dysfunction, and a study of oral health and happiness have been conducted and published.
Free Research Field	歯科疫学
Academic Significance and Societal Importance of the Research Achievements	本研究は様々な観点から分析を行い、口腔と全身の健康に関して多角的な視点からの検証を行った。手法的には、固定効果分析を用いることで未測定の要因であっても時間で不変の要因であれば影響を取り除く解析を行ったり、媒介分析で口腔と全身の間にあるメカニズムについて検討をした。理論的には、これまで口腔内細菌や歯周病による慢性炎症などの生物化学的な要因が口腔と全身の健康の間のメカニズムと考えられていたが、口腔のもつ会話や食事といった基本的な機能が、口腔と全身の健康の間に存在することを考慮し、研究を発展させた。このように手法と理論両面から、口腔と全身の国際的な研究をもけん引する研究が行えたと考えている。