2022 Fiscal Year Final Research Report

Exosomes and their miRNAs as a central role in bronchial asthma caused by environmental chemicals

Research Project

PDF

Project/Area Number	19H03882
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research Institution	Kanazawa University
Principal Investigator	NAKAMURA HIROYUKI 金沢大学, 医学系, 教授 (30231476)
Co-Investigator(Kenkyū-buntansha)	辻口博聖金沢大学, 医学系, 特任助教 (00723090) 神林康弘岡山理科大学, 獣医学部, 教授 (20345630) 早川和一金沢大学, 環日本海域環境研究センター, 連携研究員 (40115267) 尾長谷靖長崎大学, 医歯薬学総合研究科(医学系), 准教授 (40399762) 華山力成金沢大学, ナノ生命科学研究所, 教授 (40403191) 中島美紀金沢大学, ナノ生命科学研究所, 教授 (70266162) 原章規金沢大学, 医学系, 准教授 (70507045)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	気管支喘息症 / 多環芳香族炭化水素類 / 大気汚染 / エクソソーム / miRNA
Outline of Final Research Achievements	To elucidate the role of exosomes and their miRNAs released from eosinophils in the development of bronchial asthma caused by environmental chemicals such as polycyclic aromatic hydrocarbons (PAHs), we performed model mouse experiments and clinical epidemiology. Both model mouse studies and clinical epidemiology have shown interactions between chemicals such as miR-146 and asthma symptoms. These results suggest that PAHs such as benzo[a]pyrene play a significant role in eosinophils in developing bronchial asthma. Therefore, it was thought that measuring the miRNA profile of exosomes from eosinophils could prevent the onset of bronchial asthma caused by atmospheric chemicals.
Free Research Field	公衆衛生学
Academic Significance and Societal Importance of the Research Achievements	BaPなどのPAHが気管支喘息を発症する病態として、アレルギーと炎症をクロストークする役割として好酸球からエクソソームとmiRNA、特にmiR-146が同定できたことは学術的な意義が大きいと考えられる。また好酸球からエクソソームとmiRNAのプロファイルを環境中化学物質に基づく気管支喘息症のバイオマーカーとして案出できたことは、環境中化学物質による気管支喘息症発症の予防に繋がるものとして社会的な意義も大きいと考えられた。