2022 Fiscal Year Final Research Report

Development of rehabilitation method applying physical stimulation as countermeasure for sarcopenia and elucidation of its underlying molecular mechanisms

Research Project

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Project/Area Number	19H03981
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 59010:Rehabilitation science-related
Research Institution	Dokkyo Medical University
Principal Investigator	Toshiaki Nakajima 獨協医科大学, 医学部, 特任教授 (50227790)
Co-Investigator(Kenkyū-buntansha)	佐久間理吏獨協医科大学, 医学部, 准教授 (10530199) 小尾正太郎獨協医科大学, 医学部, 准教授 (10734452) 井上晃男獨協医科大学, 医学部, 特任教授 (20168454) 安田智洋聖隷クリストファー大学, 看護学部, 教授 (20549604) 福田宏嗣獨協医科大学, 医学部, 教授 (70526269) 豊田茂獨協医科大学, 医学部, 教授 (80332998) 柴崎郁子獨協医科大学, 医学部, 准教授 (80438689) 狩野豊電気通信大学, 大学院情報理工学研究科, 教授 (90293133)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	sarcopenia / muscle atrophy / rehabilitation / waon therapy / Kaatsu training / heat stress / hypoxia
Outline of Final Research Achievements	KAATSU training was introduced to patients in the early postoperative period after cardiovascular surgery, and its effects and safety were investigated. Furthermore, Waon therapy could be safely administered to elderly patients with heart failure, and it has been clarified that it is useful for improving cognitive function and maintaining muscle strength. In a basic study, a single thermal stimulus increased intracellular Ca2+ in the gastrocnemius muscle, and the phosphorylation of AKT, mTOR, and S6 significantly increased compared to controls. In addition, when thermal stimulation was applied in vivo model, an increase in muscle weight and muscle fiber diameter was observed. Gene analysis by microarray also showed that genes related to extracellular matrix were decreased. From these results, these rehabilitation methods would be very useful as a countermeasure against sarcopenia, leading to enhancement of muscle strength and QOL improvement.
Free Research Field	Rehabilitation
Academic Significance and Societal Importance of the Research Achievements	サルコペニアは, 患者のQOL, 生命予後に深く関与している. その対策として, 運動療法が推奨されている. しかし, 近未来に訪れる高齢化, 急増が予測される心不全患者では,通常のリハビリ法が困難な場合も多くなることが予測され, その対策は急務である. 本研究は, 物理的刺激を応用した和温療法ならびに加圧トレーニングが. サルコペニア患者の筋力増強, QOL改善につながる有用なリハビリ法になるという仮説を実証し, サルコペニア対策としての新規リハビリ法を開発することを目的とした. これらの物理的刺激を応用したリハビリ法は, サルコペニア対策としての有用な新規リハビリ法になると思われた.