2023 Fiscal Year Final Research Report
Development of Respiratory Rehabilitation to Improve the Prognosis of Interstitial Pneumonia by Applying Respiratory Sensory Modulation
| Project/Area Number |
19H03984
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Tohoku University (2022-2023)
Toho University (2019-2021) |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 呼吸困難 / メンソール |
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| Outline of Final Research Achievements |
In order to ensure the physiological efficacy of exercise therapy for pulmonary rehabilitation in patients with interstitial pneumonia, an uncomfortable respiratory sensory modification method was developed to ensure the amount of exercise sufficient to achieve an effect up to prognosis. As for the unpleasant breathing sensation, dyspnea during exertion was targeted. We found that dyspnea in interstitial pneumonia was efficiently improved by olfactory stimulation with menthol. A qualitative profile analysis of dyspnea revealed that menthol acts in the immediate sensory domain, while not in the affective response domain. This is different from COPD, but it was found that it was reduced in the same way as COPD in inspiratory flow perception, which is the central mechanism of action.
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| Free Research Field |
呼吸生理
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| Academic Significance and Societal Importance of the Research Achievements |
誰もが運動が体にいいことをわかってはいるが、多くの人において運動習慣が定着しているとは言い難い。その理由の一つに、運動時の呼吸困難がある。同様なことが間質性肺炎患者にも起こっている。この呼吸困難をうまく制御できれば、人々はもっと快適に運動し、運動習慣が身につき、健康寿命の延伸に繋がる。今回我々はメンソールのにおいをかぎながら運動すると、かなりの呼吸困難改善効果があることをその機序とともに明らかにした。これは間質性肺炎や慢性閉塞性肺疾患などの病態のみならず、健常人やトップアスリートなどの肺疾患がない人も同様であった。よってメンソールの嗅覚刺激を上手に使用すれば、健康寿命の延伸に大きく寄与する。
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