2021 Fiscal Year Final Research Report
Predictor of the efficacy of PRP-therapy for sports-related injuries
Project/Area Number |
19H04004
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 59020:Sports sciences-related
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Research Institution | Juntendo University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 多血小板血漿 / スポーツ外傷 / 関節炎 / 再生医療 / 変形性関節症 |
Outline of Final Research Achievements |
There has recently been growing interest worldwide in biological therapies such as platelet-rich plasma (PRP) injection for the treatment of sports-related injuries. However, predicting the effectiveness of PRP therapy remains uncertain. Therefore, this study was performed to assess a range of predictors for the effectiveness of PRP therapy. Firstly, we analyzed 517 patients who underwent platelet-rich plasma therapy. However, the efficacy of platelet-rich plasma therapy was not affected by age, sex, body weight, or platelet count. Then, we analyzed blood cell counts, including the immature platelet fraction (IPF), in peripheral blood and PRP of 144 patients with knee OA who underwent PRP therapy. This study demonstrated that the percentage of IPF (IPF%) in whole blood was positively correlated with patient-oriented outcome scores. Lastly, we evaluated the biomarkers and found that PRP-therapy decreased the chondrodestractive markers in osteoarthritis patients.
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Free Research Field |
整形外科学 スポーツ医学 再生医学
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Academic Significance and Societal Importance of the Research Achievements |
これまでPRP療法の効果を規定する因子は不明であった。我々は、PRPの質(含まれる成長因子やサイトカイン)が個人ごとに異なることを明らかにし、PRP療法の効果は血小板の数ではなくPRPの質による影響が高いことを明らかにした。このことがより効果の高い新規PRP調製法の開発に繋がれば、運動器疾患に悩む人々の治療開発に貢献できるものと考える。
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