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2021 Fiscal Year Final Research Report

Molecular basis of neural cell response to the nutritional intake of fatty acids during development

Research Project

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Project/Area Number 19H04026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionTohoku University

Principal Investigator

OWADA Yuji  東北大学, 医学系研究科, 教授 (20292211)

Co-Investigator(Kenkyū-buntansha) 香川 慶輝  東北大学, 医学系研究科, 助教 (30728887)
宮崎 啓史  東北大学, 医学系研究科, 助教 (90803867)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywordsアストロサイト / ニューロン / 脂肪酸 / ミトコンドリア
Outline of Final Research Achievements

Although higher brain functions and neurological diseases have been linked to nutritional intake, the molecular basis of the effects of lipids on the nervous system has remained unclear. In this application, we examined whether changes in lipid metabolism in nervous system cells (neurons and glial cells) are related to the regulation of genetic information (epigenetic modification) and neural plasticity. The results revealed that changes in intracellular lipid metabolism and energy production affect the stress response of glial cells and the plasticity of neurons.

Free Research Field

神経科学、栄養科学

Academic Significance and Societal Importance of the Research Achievements

脂質の摂取障害が、学習や情動などに影響を及ぼすことは栄養学的に古くから知られているが、脂質摂取の異常(あるいは脂質代謝関連遺伝子変異)と神経可塑性異常の関連性の解析は重要なテーマである。本成果は、脳機能に対する発達期栄養学的知見、すなわち発達期栄養障害仮説を起点にした脳機能や神経系疾患病態の関連理解に向けて重要な知見を提供する。未だ謎の多い精神疾患病態メカニズムの解明に向けて、新たな基礎的知見と治療アプローチを提供できると考える。

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Published: 2023-01-30  

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