Statistical Inference Based on Real-World-Data

2020 Fiscal Year Annual Research Report

• Project/Area Number: 19H04072
• Research Institution: Yokohama City University
• Principal Investigator: 汪 金芳 横浜市立大学, データサイエンス学部, 教授 (10270414)
• Co-Investigator(Kenkyū-buntansha): 田栗 正隆 横浜市立大学, データサイエンス学部, 教授 (20587589) ; 橋口 陽子 (小野陽子) 横浜市立大学, データサイエンス学部, 准教授 (60339140)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 医療データ / Real World Data / Causal Inference / Data Science / Cell Regression / Bayesian Inference

Outline of Annual Research Achievements

伝統的統計解析法を拡張し，実世界データ（Real World Data）に適したベイズ解析法を開発した。特に，大規模頻度データに焦点を当て，伝統的回帰分析法を拡張し，積分型回帰分析法（（Bayesian Cell Regression Method））を構築した。セル型ベイズ回帰分析法に基づいて，実世界データにおけるベイズ解析から得られた実事前情報を，目的データ解析に転移させ，データ駆動型客観的ベイズ推論の基礎理論を構築した。得られた結果を学術誌として纏めている最中である。具体的には、
（１）表の形で提供されている背景データの回帰モデルを構築し、予測分布に基づくセル型回帰手法を構築した。
（２）（１）の回帰手法をベーズ的拡張を行った。
（３）セル回帰を、２つ以上の表に適用した。
（４）（１）ー（３）で得られた事後分布はデータドリブンな事前情報として、第２段階のreal world data解析へ応用する手法を確立した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

概ね予定通りの理論的結果が得られている。また実データへの応用も順調に進んでいる。

Strategy for Future Research Activity

Real World Dataについてさらなる解析を行い、構築した理論を実テータへ応用し、理論の拡張と共にその有用性を確かめる。

Research Products

• [Journal Article] TITE-BOIN-ET: Time-to-event Bayesian optimal interval design to accelerate dose-finding based on both efficacy and toxicity outcomes. (2020)
  • Author(s): Takeda K, Morita S, Taguri M.
  • Journal Title: Pharm Stat. Volume: 19 Pages: 335-349.
  • Peer Reviewed
• [Journal Article] Minimally invasive versus standard endoscopic combined intrarenal surgery for renal stones: a retrospective pilot study analysis (2020)
  • Author(s): Usui K, Komeya M, Taguri M, Kataoka K, Asai T, Ogawa T, Yao M, Matsuzaki J
  • Journal Title: Int Urol Nephrol Volume: 52 Pages: 1219-1225
  • Peer Reviewed
• [Journal Article] Investigation of Computed-Tomography Based Predictors of Acute Stroke Related to Transcatheter Aortic Valve Replacement: Aortic Wall Plaque Thickness Might be a Predictive Parameter of Stroke (2020)
  • Author(s): Miyasaka M, Sharma RP, Maeno Y, Taguri M, Yoon SH, Kawamori H, Tada N, Kato S, Israr S, Nomura T, Ochiai T, Abramowitz Y, Chakravarty T, Nakamura M, Cheng W, Friedman JD, Berman DS, Makkar RR
  • Journal Title: J Invasive Cardiol Volume: 32 Pages: 18-26
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Does screening for prostate cancer improve cancer-specific mortality in Asian men? Real-world data in Yokosuka City 15 years after introducing PSA-based population screening (2020)
  • Author(s): Tabei T, Taguri M, Sakai N, Koh H, Yosida M, Fujikawa A, Nirei T, Tsutsumi S, Ito H, Furuhata S, Kawahara T, Miyoshi Y, Noguchi S, Uemura H, Kobayashi K
  • Journal Title: Prostate Volume: 80 Pages: 824-830
  • Peer Reviewed
• [Journal Article] Relationship between Programmed Cell Death Protein Ligand 1 Expression and Immune-related Adverse Events in Non-small-cell Lung Cancer Patients Treated with Pembrolizumab (2020)
  • Author(s): Sugisaka J, Toi Y, Taguri M, Kawashima Y, Aiba T, Kawana S, Saito R, Aso M, Tsurumi K, Suzuki K, Shimizu H, Ono H, Domeki Y, Terayama K, Nakamura A, Yamanda S, Kimura Y, Honda Y, Sugawara S
  • Journal Title: JMA J Volume: 3 Pages: 58-66
  • Peer Reviewed
• [Journal Article] Access-site complications of transradial percutaneous coronary intervention using sheathless guiding catheters for acute coronary syndrome: a prospective cohort study with radial ultrasound follow-up (2020)
  • Author(s): Isawa T, Horie K, Taguri M, Ootomo T
  • Journal Title: Cardiovasc Interv Ther Volume: 35 Pages: 343-352
  • Peer Reviewed
• [Journal Article] Comparing the effectiveness of magnesium oxide and naldemedine in preventing opioid-induced constipation: a proof of concept, single institutional, two arm, open-label, phase II, randomized controlled trial: the MAGNET study. (2020)
  • Author(s): Ozaki A, Kessoku T, Iwaki M, Kobayashi T, Yoshihara T, Kato T, Honda Y, Ogawa Y, Imajo K, Higurashi T, Yoneda M, Taguri M, Yamanaka T, Ishiki H, Kobayashi N, Saito S, Ichikawa Y, Nakajima A
  • Journal Title: Trials Volume: 21 Pages: 453
  • Peer Reviewed
• [Journal Article] Serum surfactant protein A as a surrogate biomarker of a negative heart sign among patients with interstitial lung disease (2020)
  • Author(s): Sasaki H, Hara Y, Taguri M, Fujikura Y, Murohashi K, Yagyu H, Kaneko T, Kawana A
  • Journal Title: Nagoya J Med Sci. Volume: 82 Pages: 499-508
  • Peer Reviewed
• [Journal Article] Predictors of the need for supportive femoral approach during transvenous extraction of pacemaker and defibrillator leads in Japanese patients (2020)
  • Author(s): Isawa T, Honda T, Yamaya K, Taguri M
  • Journal Title: J Arrhythm Volume: 36 Pages: 746-754
  • Peer Reviewed
• [Journal Article] Slender Sheath/Guiding Catheter Combination vs. Sheathless Guiding Catheter for Acute Coronary Syndrome: A Propensity-Matched Analysis of the Two Devices (2020)
  • Author(s): Isawa T, Horie K, Honda T, Taguri M, Tada N
  • Journal Title: J Interv Cardiol Volume: 2020 Pages: 821-831
  • Peer Reviewed
• [Journal Article] Lack of a bridge between screening and medical management for hypertension: health screening cohort in Japan (2020)
  • Author(s): Fukuma S, Ikenoue T, Saito Y, Yamada Y, Saigusa Y, Misumi T, Taguri M
  • Journal Title: BMC Public Health Volume: 20 Pages: 1419
  • Peer Reviewed
• [Journal Article] In-Hospital Mortality in Acute Myocardial Infarction According to Population Density and Primary Angioplasty Procedures Volume (2020)
  • Author(s): Matsuzawa Y, Konishi M, Nakai M, Saigusa Y, Taguri M, Gohbara M, Ebina T, Kosuge M, Hibi K, Nishimura K, Miyamoto Y, Yasuda S, Ogawa H, Saito Y, Nakayama N, Takeuchi I, Tamura K, Kimura K
  • Journal Title: Circ J Volume: 84 Pages: 1140-1146
  • Peer Reviewed
• [Journal Article] OCEAN-TAVI investigators. Patients' characteristics and mortality in urgent/emergent/salvage transcatheter aortic valve replacement: insight from the OCEAN-TAVI registry (2020)
  • Author(s): Enta Y, Miyasaka M, Taguri M, Tada N, Hata M, Watanabe Y, Naganuma T, Yamawaki M, Yamanaka F, Shirai S, Ueno H, Mizutani K, Tabata M, Takagi K, Yamamoto M, Hayashida K
  • Journal Title: Open Heart Volume: 7 Pages: e001467
  • Peer Reviewed
• [Journal Article] Histopathological validation of magnifying endoscopy for diagnosis of mixed-histological-type early gastric cancer (2020)
  • Author(s): Ozeki Y, Hirasawa K, Kobayashi R, Sato C, Tateishi Y, Sawada A, Ikeda R, Nishio M, Fukuchi T, Makazu M, Taguri M, Maeda S
  • Journal Title: World J Gastroenterol Volume: 26 Pages: 5450-5462
• [Journal Article] Outcomes of treatment for localized prostate cancer in a single institution: comparison of radical prostatectomy and radiation therapy by propensity score matching analysis (2020)
  • Author(s): Hayashi N, Osaka K, Muraoka K, Hasumi H, Makiyama K, Kondo K, Nakaigawa N, Yao M, Mukai Y, Sugiura M, Takano S, Ito E, Kaizu H, Koike I, Hata M, Taguri M, Miyoshi Y, Izumi K, Kawahara T, Uemura H
  • Journal Title: World J Urol Volume: 38 Pages: 2477-2484
  • Peer Reviewed
• [Journal Article] Impact of Scoring Balloons on Percutaneous Transluminal Angioplasty Outcomes in Femoropopliteal Lesions (2020)
  • Author(s): Horie K, Tanaka A, Taguri M, Inoue N
  • Journal Title: J Endovasc Ther Volume: 27 Pages: 481-491
  • Peer Reviewed
• [Journal Article] Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial (2020)
  • Author(s): Kamata Y, Kessoku T, Shimizu T, Kobayashi T, Kurihashi T, Sato S, Kuraji S, Aoyama N, Iwasaki T, Takashiba S, Hamada N, Kodama T, Tamura T, Ino S, Higurashi T, Taguri M, Yamanaka T, Yoneda M, Usuda H, Wada K, Nakajima A, Minabe M
  • Journal Title: Trials Volume: 291 Pages: 291
  • Peer Reviewed
• [Journal Article] Predictive Ability of Preoperative PT-INR and Postoperative MCP1 for Post-hepatectomy Liver Failure (2020)
  • Author(s): Arisaka S, Matsuyama R, Goto K, Suwa Y, Mori R, Morioka D, Taguri M, Endo I
  • Journal Title: In Vivo Volume: 34 Pages: 1255-1263
  • Peer Reviewed
• [Journal Article] Effect of liraglutide on lipids in patients with type 2 diabetes: a pilot study (2020)
  • Author(s): Aoki K, Kamiyama H, Takihata M, Taguri M, Shibata E, Shinoda K, Yoshii T, Nakajima S, Terauchi Y
  • Journal Title: Endocr J Volume: 67 Pages: 957-962
  • Peer Reviewed
• [Journal Article] Preoperative predictors of lymph node metastasis in clinical T1 adenocarcinoma (2020)
  • Author(s): Nakahashi K, Tsunooka N, Hirayama K, Matsuno M, Endo M, Akahira J, Taguri M
  • Journal Title: J Thorac Dis Volume: 12 Pages: 2352-2360
  • Peer Reviewed
• [Journal Article] Prenatal clinical manifestations in individuals with COL4A1/2 variants (2020)
  • Author(s): Itai T, et al.
  • Journal Title: J Med Genet. Volume: 未定 Pages: (in press)
  • Peer Reviewed
• [Journal Article] Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial. (2020)
  • Author(s): Kessoku T, Imajo K, Kobayashi T, Ozaki A, Iwaki M, Honda Y, Kato T, Ogawa Y, Tomeno W, Kato S, Higurashi T, Yoneda M, Kirikoshi H, Kubota K, Taguri M, Yamanaka T, Usuda H, Wada K, Kobayashi N, Saito S, Nakajima A
  • Journal Title: Lancet Gastroenterol Hepatol Volume: 5 Pages: 996-1007
  • Peer Reviewed
• [Journal Article] Factors influencing interruption of colorectal endoscopic submucosal dissection (2020)
  • Author(s): Fukuchi T, Hirasawa K, Sato C, Makazu M, Kaneko H, Kobayashi R, Nishio M, Ikeda R, Sawada A, Taguri M, Maeda S
  • Journal Title: Surg Endosc Volume: 未定 Pages: (in press)
  • Peer Reviewed
• [Journal Article] Erratum to "Slender Sheath/Guiding Catheter Combination vs. Sheathless Guiding Catheter for Acute Coronary Syndrome: A Propensity-Matched Analysis of the Two Devices" (2020)
  • Author(s): Isawa T, Horie K, Honda T, Taguri M, Tada N.
  • Journal Title: J Interv Cardiol Volume: 2020 Pages: 1303764
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Third-look endoscopy prevents delayed bleeding after endoscopic submucosal dissection under antithrombotic therapy (2020)
  • Author(s): Ikeda R, Hirasawa K, Sato C, Ozeki Y, Sawada A, Nishio M, Fukuchi T, Kobayashi R, Makazu M, Taguri M, Maeda S
  • Journal Title: World J Gastroenterol Volume: 26 Pages: 6475-6487
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Real impact of tumor marker AFP and PIVKA-II in detecting very small hepatocellular carcinoma (<= 2 cm, Barcelona stage 0) - assessment with large number of cases. (2020)
  • Author(s): Tarao K, Nozaki A, Komatsu H, Komatsu T, Taguri M, Tanaka K, Chuma M, Numata K, Maeda S
  • Journal Title: World J Hepatol Volume: 12 Pages: 1046-1054
  • Peer Reviewed
• [Presentation] 因果媒介分析を極める！~直接効果・間接効果の推定~ (2021)
  • Author(s): 田栗正隆
  • Organizer: 第31回日本疫学会学術総会
• [Presentation] ビッグデータを用いた因果推論：観察研究データを用いた標的臨床試験の模倣 (2021)
  • Author(s): 田栗正隆
  • Organizer: 日本臨床試験学会 第12回学術集会総会
• [Presentation] Discussion on ‘Some of the Challenges of Statistical Applications’ by Dr Copas (2020)
  • Author(s): 田栗正隆
  • Organizer: 2020年度統計関連学会連合大会
  • Invited
• [Presentation] 「大学におけるモデルカリキュラム：データリテラシーの涵養」のための放送教材開発 (2020)
  • Author(s): 小野 陽子
  • Organizer: 2020年度統計関連学会連合大会
• [Presentation] モード２科学としてのデータサイエンスと Yokohama D-STEP (2020)
  • Author(s): 汪金芳
  • Organizer: 第18回統計教育方法論WS
• [Book] 弱点克服大学生の統計学 (2020)
  • Author(s): 汪 金芳, 小野 陽子, 小泉 和之, 田栗 正隆, 土屋 隆裕, 藤田 慎也
  • Total Pages: 223
  • Publisher: 東京書籍
  • ISBN: 4489023375
• [Book] 統計検定準1級対応 統計学実践ワークブック (2020)
  • Author(s): 日本統計学会編（分担執筆）
  • Total Pages: 330
  • Publisher: 学術図書出版社