2022 Fiscal Year Final Research Report
Development of cartilage regeneration micropatterned substrates that promote strong cartilage-bone junctions
Project/Area Number |
19H04448
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 90110:Biomedical engineering-related
|
Research Institution | University of the Ryukyus |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
清水 雄介 琉球大学, 医学(系)研究科(研究院), 教授 (10327570)
東 千夏 琉球大学, 病院, 講師 (60579085)
|
Project Period (FY) |
2019-04-01 – 2022-03-31
|
Keywords | 軟骨再生 / マイクロパターン / 脂肪幹細胞 / 石灰化層 / アグリカン / I型コラーゲン / 関節軟骨 / 再生治療 |
Outline of Final Research Achievements |
In this study, we develop micropatterned base materials that create strong bonds between the cartilage and the bone. When a defective part of the articular cartilage is treated regeneratively, it is important to form a thick cartilage tissue bonding strongly with the bone. We have succeeded in forming the thick cartilage tissue by differentiation induction of adipose derived stem cells into the cartilage on micropatterned base materials having optimized shapes. It was also confirmed that the calcification was promoted on the micropatterned base materials. These results suggest that we can produce the thick cartilage tissue in which the cartilage and the bone are strongly bonded to each other when adipose derived stem cells are induced differentiation into the cartilage on micropatterned base materials with optimized shapes. In this study, we developed micropatterned base materials for cartilage regeneration, which creates the thick cartilage tissue bonding strongly with the bone.
|
Free Research Field |
再生医工学、生物物理学、界面科学、高分子化学
|
Academic Significance and Societal Importance of the Research Achievements |
本研究で得られた知見は、軟骨と骨の界面の構造が強固な軟骨-骨接合を生むメカニズムの解明に大いに貢献するものである。また、本研究で開発されたマイクロパターン基材は、軟骨と骨を強固に接合させる新しい軟骨再生治療技術の創出に繋がると考えている。更に、こういった軟骨と骨との接合を重視した新しい軟骨再生治療技術は、腱や靱帯を骨と強固に接合させるような高度な再生治療技術へと発展していく可能性が高い。
|