Development of evaluation method to develop mushroom cultivation method aiming at functional enhancement in a short time.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K02327
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 08030:Family and consumer sciences, and culture and living-related
• Research Institution: Minami Kyusyu University (2020-2021); DAIICHI UNIVERSITY OF TECHNOLOGY (2019)
• Principal Investigator: Yoshimoto Hiroaki 南九州大学, 健康栄養学部, 教授 (30516919)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: きのこ / 機能性 / 栽培法 / NF-kappa B / ヒラタケ / ヒメマツタケ

Outline of Final Research Achievements

Mushrooms contribute to human health. The health benefits of mushrooms can be enhanced by reorganizing cultivation methods, but they actually require a lot of cost and time. In this study, we searched for a simple index to develop a cultivation method that enhances the pharmacological effect of mushrooms. We targeted NF-kB inhibitory activity, which is located upstream of the anti-inflammatory mechanism, under the hypothesis that the various pharmacological effects of mushrooms are due to their anti-inflammatory effects. As a result of examining the correlation between the NF-kB inhibitory activity and various functions, it was suggested that the NF-kB inhibitory activity is effective as an index explaining the anti-inflammatory effect of mushrooms. In the future, we think that it will be possible to implement it in society by examining detailed conditions.

Free Research Field

きのこ学

Academic Significance and Societal Importance of the Research Achievements

超高齢化社会を迎えた日本にとって、健康寿命の延伸は重要な課題である。医療の進歩は著しいが、一方で国民経済を圧迫しているのも事実である。きのこは古来漢方薬にも利用され国民に親しまれているとともに、その多彩な薬理作用は、医薬品にも比肩する高い効果が証明されている。したがって、食事に多くのきのこを取り入れることは国民経済的にも意義深いが、一方で機能性が低い栽培法も存在し、機能性を考慮した栽培法の開発も不可欠である。本研究は、きのこ栽培を機能性の観点から改変するための指標を探索するという点で独創的であり、かつ社会的に意義の高い研究であると言える。