Effects of the onset of nonalcoholic fatty liver disease on eating behavior

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K02352
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 08030:Family and consumer sciences, and culture and living-related
• Research Institution: Hirosaki University
• Principal Investigator: YAMAMOTO Ryoko 弘前大学, 農学生命科学部, 助教 (50580429)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: NAFLD / NASH / 摂食

Outline of Final Research Achievements

The aim of this study was to clarify the effects of the onset of nonalcoholic fatty liver disease (NAFLD) on feeding behavior. The amount of food ingested tended to increase with the onset of NAFLD. In the NAFDL mice, there was fat accumulation in the liver region, but less visceral fat accumulation. As a result, even though energy intake was increased, leptin secretion was low, suggesting that the regulation of feeding might not be fully function. However, the analysis of central regulation of feeding was insufficient in this study, and further studies are needed.

Free Research Field

食生活学

Academic Significance and Societal Importance of the Research Achievements

非アルコール性脂肪性肝疾患は世界的にも罹患者数が増加しており、我が国においても成人の約30%が罹患している新たな国民病ともいわれている。病気の発症・予防には食生活の改善が重要な鍵を握るといわれていることから、病態発症時の食行動の研究を行うことは学術的にも社会的にも重要である。