2022 Fiscal Year Final Research Report
Symmetry Classification of Universality on Pattern Formation of Collective Cell Motion
| Project/Area Number |
19K03770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 集団運動 / 極性対称性 / 細胞接着 / 運動秩序形成 / パターン形成 |
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| Outline of Final Research Achievements |
We investigate the relation between the symmetry of cells and collective cell migration. We consider the three symmetric classes of surface tension. In the cell scale, The rotationally-symmetric class induces aggregation or suspending state of cells. The polar class in tension induces the driving force of migrating cells. The apolar class in tension induces cell elongation in the direction of polarity. We attempt to clarify the collective cell migration on these symmetric classes. The rotationally-symmetric class stabilizes the cellular configuration, inducing a macroscopic transition from a fluctuated collective motion to a stable long-distance motion. The polar class stabilizes the array pattern in collective migration. Finally, the apolar class stabilizes the nematic pattern in the collective cell migration except for symmetric rotational points. We also consider the boundary between polar-rotational symmetric cells and show relativistic stable and mixing disorder motions.
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| Free Research Field |
統計物理学
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| Academic Significance and Societal Importance of the Research Achievements |
自発的に運動するアクティブマターの巨視的な振る舞いはその対称性で分類されるとされてきた. 細胞の集団はその重要な例とされてきた. 現状のところその分類の実際に真核細胞へ適用はすすんでいない.この適用は実験的には困難であるが, 理論的な模型であれば比較的容易に調べることができる.本研究はCellular Potts模型を利用して対称性と 少なくとも
我々はこの研究を通して細胞の張力の対称性と集団運動の関係を整理した. 少なくとも極型のものに関しては知られた秩序状態が安定するが, 回転対称で駆動がある場合や非極性の場合での秩序形成などそれほど単純でないことが判ってきた.
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