2022 Fiscal Year Final Research Report
Highly regioselective carbon-hydrogen bond direct boronation using substrate functional groups and metal catalyst ligands
| Project/Area Number |
19K05449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 33020:Synthetic organic chemistry-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 炭素ー水素結合活性化 / ホウ素化 |
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| Outline of Final Research Achievements |
Regioselective boronation of different carbon-hydrogen bonds in arenes was successfully developed. Successfully developed regioselective boronation of different carbon-hydrogen bonds in heteroarenes.Successfully developed direct boronation of vinyl carbon-hydrogen bonds of alkenes with sp2 carbon-hydrogen bonds similar to arenes and heteroarenes. We clarified the effective use of the developed boronation reaction for the synthesis of physiologically active substances, natural products, and functional organic materials.
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| Free Research Field |
有機合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
有機ホウ素化合物は、取扱いの容易さや低毒性とともに活性化剤の使い分けによる反応制御の容易さから、現代の精密有機合成に欠かすことのできない重要な試薬となっている。
本研究では、遷移金属触媒による炭素―水素結合の活性化に基づくホウ素化反応の開発、特に同一基質でも置換基の立体効果および配位効果を配位子の種類を使い分けることにより、異なる位置を高選択的にホウ素化する触媒系の開発、反応機構と一般性の解明、および有機合成への有効利用を目的とし、以下の成果を得た。
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