2021 Fiscal Year Final Research Report
Microwave-assisted synthesis of infection inhibitor for Japanese encephalitis virus
| Project/Area Number |
19K05731
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 37030:Chemical biology-related
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| Research Institution | Aichi University of Education |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
左 一八 会津大学短期大学部, 食物栄養学科, 教授 (20260226)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | ウイルス感染阻害剤 / 日本脳炎 / ウロン酸 / 化合物ライブラリー / 糖質化学 |
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| Outline of Final Research Achievements |
To date, there is no effective treatment for Japanese encephalitis in clinical practice, and symptomatic therapy is the basic treatment for patients affected by Japanese encephalitis virus (JEV). The development of effective anti-JEV drugs is urgently needed to prevent the epidemic and spread of JEV infection in the future and to improve the prognosis of those affected by the disease. In this study, since chondroitin sulfate E (CS-E) shows JEV infection inhibitory activity, we designed uronic acids with double bonds or sulfate groups, and hybrid uronic acids of glucuronic acid and N-acetylgalactosamine, a repeating disaccharide unit of CS-E, and found compounds with effective JEV infection inhibitory activity through the synthesis and library preparation of them.
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| Free Research Field |
糖質化学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、CS-Eが、強力なJEV感染阻害活性を示すことから、CS-Eを構成するグルクロン酸、N-アセチルガラクトサミン構造を基本に、硫酸基結合数およびその結合位置の異なる低分子糖誘導体やそれらのハイブリッド型をデザインし、密閉反応装置を積極的に利用して化学合成し、有効なJEV感染阻害活性を有する化合物を探索・同定を行った。JEVの吸着を阻害する化合物は、JEVの宿主認識メカニズムの解明に重要であり、抗JEV薬開発に繋がるリード化合物につながる化合物を本研究期間内に見出すことができた。
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