2023 Fiscal Year Final Research Report
The analysis of asthma remedy by negi extract in sg III knockout mice
| Project/Area Number |
19K05882
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Akita Prefectural University |
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Principal Investigator |
Iwashita Jun 秋田県立大学, 生物資源科学部, 准教授 (70315597)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | muc5ac / ムチン / 分泌 / ４型コラーゲン |
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| Outline of Final Research Achievements |
Patients with respiratory diseases such as asthma have excessive mucus secretion in the airways, mainly mucin. We have studied the regulation of mucin secretion by the extracellular matrix (ECM), which is a major component of the airway. We obtained the results that type 4 collagen suppresses mucin production and secretion in model mice via phosphorylase ERK and other pathways, and reported the results in an overseas journal. Other small molecules contained in food suppress mucin secretion in cultured cells and in the airways of mice, and these results are useful.
We also analyzed the function of SgIII in mucin secretion, but the increase in MUC5AC in knockout mice induced by OVA was small and difficult to analyze. We are continuing our analysis while changing the analysis method.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
喘息などの呼吸器疾患のある患者の気道において過剰に分泌される粘液ムチンの抑制は、その症状改善につながるため注目されている。本研究で培養細胞、そして生体マウスにおいて、ECMの主要な成分である４型コラーゲン投与や根深ネギ成分の投与により、気道でのムチン過剰分泌の抑制されることを報告した。この結果は喘息の症状改善に、コラーゲンなどの成分が有効である可能性を示しており、社会的に有意義な発見である。
また生体マウスの気道におけるERKなどの活性の変動についても同時に解析を行い、学術的に意義ある結果を得ることができた。
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