2021 Fiscal Year Final Research Report
Study on food functions and metabolism of plasmalogen in colon
| Project/Area Number |
19K05892
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | プラズマローゲン / 大腸腺腫 / 腸炎 |
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| Outline of Final Research Achievements |
In the present study, we investigated the effects of plasmalogen intake on colon impairments. Their evaluation were applied to in vivo the mouse models of colon inflammation and the formation of aberrant crypt foci, and in vitro the intestinal inflammation. As result, continuous administration of plasmalogen bearing EPA and DHA may prevent colon impairments including inflammatory bowel disease and colon cancer. It is hypothesized that plasmalogen absorbed into the intestinal epithelium suppresses the first step of inflammatory reactions to alleviate the development of the impairments.
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| Free Research Field |
食品科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究において、プラズマローゲン摂取による新しい機能性知見として、大腸疾患予防効果が明らかとなった。近年、生活習慣の変化が原因と考えられる大腸疾患罹患者が増加しており、それら疾患の予防法あるいは症状改善法に対する社会的ニーズは高い。また、腸は栄養吸収だけではなく、免疫および神経行動とのかかわりも深い。したがって、本研究による腸管保護作用に関する知見は、社会的意義に加え、プラズマローゲンのさらなる可能性を示した点で学術的意義も大きいと考える。
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