Mechanism of vitamin C on gene expression in human epidermis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K05902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Hokuriku University
• Principal Investigator: Sato Yasunori 北陸大学, 薬学部, 講師 (40582367)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 表皮 / ビタミンC / エピジェネティクス

Outline of Final Research Achievements

Vitamin C acts as an antioxidant and as a cofactor for collagen polymerization reaction. Besides these functions, vitamin C may regulate gene expression via epigenetic modification. However, the function of vitamin C on gene expression is not fully elucidated in normal tissue. In this study, we found that vitamin C regulate gene expression using human epidermis equivalent model. Our results indicate that vitamin C may regulate gene expression in normal tissue.

Free Research Field

衛生化学、薬学

Academic Significance and Societal Importance of the Research Achievements

これまで抗酸化作用やコラーゲン重合などが大きく注目されていたビタミンCについて、遺伝子発現調節という新たな生理作用を有することが強く示唆された。本研究成果を表皮再生医療や皮膚科学の進展に寄与し、国民の栄養素に対する意識改善につながることが強く期待される。