Roles of central cellular signaling factors in feeding regulation of chickens

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K06353
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42010:Animal production science-related
• Research Institution: Kobe University
• Principal Investigator: Kamisoyama Hiroshi 神戸大学, 農学研究科, 教授 (90263889)
• Co-Investigator(Kenkyū-buntansha): 實安 隆興 神戸大学, 農学研究科, 助教 (20721236)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 食欲調節 / Smad / GLP-1 / GLP-2 / PYY / ニワトリ / 視床下部 / 延髄

Outline of Final Research Achievements

The present study suggests the following points;
An activation of central Smad signaling suppresses food intake in chickens, but it might not occur under physiological conditions. In layer (egg type) chickens, upregulation of Akt and ERK signaling in the medulla oblongata suppresses food intake, and insulin is involved in the upregulation. On other hand, Akt and p38MAPK, but not ERK, in the medulla oblongata are involved in feeding regulation in broiler (meat type) chickens. Akt and ERK in the medulla oblongata are not involved in suppression of food intake induced by cholecystokinin, glucagon-like peptide (GLP)-1, and GLP-2.

Free Research Field

栄養飼養

Academic Significance and Societal Importance of the Research Achievements

本研究により明らかになったブロイラーとレイヤーにおける違いは、ニワトリの摂食調節機構の全容解明に貢献し得ると共に、ブロイラーにおける食欲制御方法の開発の基礎にもなり得る。また、ブロイラー延髄のp38MAPKが摂食調節に関与している可能性が本研究で示されたが、このような報告は哺乳類の研究においても未だないことから、本研究の成果はニワトリだけでなく哺乳類の摂食調節に関する研究の伸展にも貢献し得る。